N-(4-fluorobenzyl)-2-(benzyloxy)-7-trifluoromethyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide

Base Information

Chemical Name:N-(4-fluorobenzyl)-2-(benzyloxy)-7-trifluoromethyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide
CAS No.:1609575-94-1
Molecular Formula:C₂₅H₁₈F₄N₂O₄
Molecular Weight:486.423
Hs Code.:

Synonyms:N-(4-fluorobenzyl)-2-(benzyloxy)-7-trifluoromethyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide

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Chemical Property of N-(4-fluorobenzyl)-2-(benzyloxy)-7-trifluoromethyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide

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Technology Process of N-(4-fluorobenzyl)-2-(benzyloxy)-7-trifluoromethyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide

There total 5 articles about N-(4-fluorobenzyl)-2-(benzyloxy)-7-trifluoromethyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1609575-89-4
methyl 2-(benzyloxy)-7-trifluoromethyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylate

: 140-75-0
para-fluorobenzylamine

: 1609575-94-1
N-(4-fluorobenzyl)-2-(benzyloxy)-7-trifluoromethyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide

Guidance literature:: In toluene; Reflux; Dean-Stark;
DOI:10.1021/jm500109z

Reference yield:

: 1609575-81-6
methyl 5-trifluoromethyl-2-(1,3-dimethoxy-1,3-dioxopropan-2-yl)benzoate

: 1609575-94-1
N-(4-fluorobenzyl)-2-(benzyloxy)-7-trifluoromethyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / Reflux; Dean-Stark

2: potassium hydroxide / methanol / 20 °C

3: toluene / Reflux; Dean-Stark

With potassium hydroxide; In methanol; toluene;
DOI:10.1021/jm500109z

Reference yield:

: 1483-56-3
2-bromo-5-(trifluoromethyl)benzoic acid

: 1609575-94-1
N-(4-fluorobenzyl)-2-(benzyloxy)-7-trifluoromethyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: copper(I) bromide; sodium hydride / mineral oil; toluene / 2.5 h / 75 °C / Inert atmosphere

2: thionyl chloride / 16 h / 0 °C / Reflux

3: toluene / Reflux; Dean-Stark

4: potassium hydroxide / methanol / 20 °C

5: toluene / Reflux; Dean-Stark

With thionyl chloride; sodium hydride; potassium hydroxide; copper(I) bromide; In methanol; toluene; mineral oil;
DOI:10.1021/jm500109z