(2R)-2-tert-butoxycarbonylamino-N-methoxy-3-(2-methoxybenzyloxy)-N-methylpropionamide

Base Information

Chemical Name:(2R)-2-tert-butoxycarbonylamino-N-methoxy-3-(2-methoxybenzyloxy)-N-methylpropionamide
CAS No.:338461-17-9
Molecular Formula:C₁₈H₂₆N₂O₇
Molecular Weight:382.414
Hs Code.:

Synonyms:(2R)-2-tert-butoxycarbonylamino-N-methoxy-3-(2-methoxybenzyloxy)-N-methylpropionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-2-tert-butoxycarbonylamino-N-methoxy-3-(2-methoxybenzyloxy)-N-methylpropionamide

Chemical Property:

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Technology Process of (2R)-2-tert-butoxycarbonylamino-N-methoxy-3-(2-methoxybenzyloxy)-N-methylpropionamide

There total 1 articles about (2R)-2-tert-butoxycarbonylamino-N-methoxy-3-(2-methoxybenzyloxy)-N-methylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 21615-34-9
2-Methoxybenzoyl chloride

: 167102-61-6
tert-butyl N-[(1R)-1-(hydroxymethyl)-2-[methoxy(methyl)amino]-2-oxo-ethyl]carbamate

: 338461-17-9
(2R)-2-tert-butoxycarbonylamino-N-methoxy-3-(2-methoxybenzyloxy)-N-methylpropionamide

Guidance literature:: With dmap; triethylamine; at 20 ℃; pH=13;
DOI:10.1016/S0040-4020(01)00012-6

Reference yield: 100.0%

: 338461-17-9
(2R)-2-tert-butoxycarbonylamino-N-methoxy-3-(2-methoxybenzyloxy)-N-methylpropionamide

: 338461-18-0
(2R)-3-hydroxy-N-methoxy-2-(2-methoxybenzoylamino)-N-methylpropionamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3.5h;
DOI:10.1016/S0040-4020(01)00012-6

Reference yield:

: 338461-17-9
(2R)-2-tert-butoxycarbonylamino-N-methoxy-3-(2-methoxybenzyloxy)-N-methylpropionamide

: 69772-54-9
(4'R,2''R,4''R)-2'-(2-hydroxyphenyl)-3''-methyl-2'',3'',4'',4',5'-hexahydro-[2,4']-bisthiazolyl-4''-carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: 100 percent / TFA / CH₂Cl₂ / 3.5 h / 20 °C

2.1: 81 percent / BCl₃ / CH₂Cl₂; hexane / 20 °C

3.1: Burgess reagent / tetrahydrofuran / Heating

3.2: 85 percent / Et₃N; H₂S / methanol / 120 h / 20 °C

4.1: 70 percent / Burgess reagent / tetrahydrofuran / Heating

5.1: 84 percent / imidazole / dimethylformamide / 2 h / 20 °C

6.1: LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

7.1: AcOK / methanol / 20 °C

8.1: 25.0 mg / TBAF / tetrahydrofuran / 0.5 h / 20 °C

9.1: ZnCl₂ / methanol

With 1H-imidazole; lithium aluminium tetrahydride; Burgess Reagent; tetrabutyl ammonium fluoride; potassium acetate; boron trichloride; trifluoroacetic acid; zinc(II) chloride; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)00012-6