Acetic acid (S)-1-(4-fluoro-phenyl)-3-{(3R,4S)-1-(4-fluoro-phenyl)-2-oxo-4-[4-((2S,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-azetidin-3-yl}-propyl ester

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Chemical Name:Acetic acid (S)-1-(4-fluoro-phenyl)-3-{(3R,4S)-1-(4-fluoro-phenyl)-2-oxo-4-[4-((2S,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-azetidin-3-yl}-propyl ester
CAS No.:190448-62-5
Molecular Formula:C₄₀H₄₁F₂NO₁₃
Molecular Weight:781.761
Hs Code.:

Acetic acid (S)-1-(4-fluoro-phenyl)-3-{(3R,4S)-1-(4-fluoro-phenyl)-2-oxo-4-[4-((2S,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-azetidin-3-yl}-propyl ester

Synonyms:Acetic acid (S)-1-(4-fluoro-phenyl)-3-{(3R,4S)-1-(4-fluoro-phenyl)-2-oxo-4-[4-((2S,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-azetidin-3-yl}-propyl ester

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Chemical Property of Acetic acid (S)-1-(4-fluoro-phenyl)-3-{(3R,4S)-1-(4-fluoro-phenyl)-2-oxo-4-[4-((2S,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-azetidin-3-yl}-propyl ester

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Technology Process of Acetic acid (S)-1-(4-fluoro-phenyl)-3-{(3R,4S)-1-(4-fluoro-phenyl)-2-oxo-4-[4-((2S,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-azetidin-3-yl}-propyl ester

There total 4 articles about Acetic acid (S)-1-(4-fluoro-phenyl)-3-{(3R,4S)-1-(4-fluoro-phenyl)-2-oxo-4-[4-((2S,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-azetidin-3-yl}-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74808-10-9
O-(2,3,4,6-Tetra-O-acetyl-α-D-glucopyranosyl)trichloroacetimidate

: 190448-46-5,1044664-24-5
(1S)-1-(4-fluorophenyl)-3-[(2S,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]propyl acetate

: 190448-62-5
Acetic acid (S)-1-(4-fluoro-phenyl)-3-{(3R,4S)-1-(4-fluoro-phenyl)-2-oxo-4-[4-((2S,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-azetidin-3-yl}-propyl ester

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at -20 ℃; for 2.5h;
DOI:10.1002/anie.200460348

Reference yield:

: 83-87-4,604-68-2,604-69-3,2152-77-4,4026-35-1,4163-59-1,4163-60-4,4163-61-5,4163-65-9,4257-94-7,4257-96-9,16299-15-3,19186-39-1,19189-55-0,25878-60-8,25941-03-1,32445-48-0,32445-49-1,32445-53-7,32445-54-8,34685-58-0,34685-59-1,43168-42-9,43168-44-1,43169-22-8,43169-25-1,66966-07-2,70749-17-6,80184-01-6,93221-01-3,93221-02-4,99630-88-3,109215-53-4,115792-70-6,115792-73-9,139894-92-1,139973-25-4,144071-49-8,147648-81-5
D-glucose pentaacetate

: 190448-62-5
Acetic acid (S)-1-(4-fluoro-phenyl)-3-{(3R,4S)-1-(4-fluoro-phenyl)-2-oxo-4-[4-((2S,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-azetidin-3-yl}-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / hydrazine acetate / dimethylformamide / 20 h / 55 °C

2: 82 percent / Cs₂CO₃ / CH₂Cl₂ / 3 h

3: BF₃*OEt₂ / CH₂Cl₂ / 2.5 h / -20 °C

With boron trifluoride diethyl etherate; hydrazinium monoacetate; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.200460348

Reference yield:

: 3947-62-4,10343-06-3,19235-21-3,22554-70-7,22860-22-6,47339-09-3,57884-82-9,62057-79-8,70191-05-8,109525-54-4,140147-37-1,6207-76-7
2,3,4,6-tetraacetylglucose

: 190448-62-5
Acetic acid (S)-1-(4-fluoro-phenyl)-3-{(3R,4S)-1-(4-fluoro-phenyl)-2-oxo-4-[4-((2S,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-azetidin-3-yl}-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / Cs₂CO₃ / CH₂Cl₂ / 3 h

2: BF₃*OEt₂ / CH₂Cl₂ / 2.5 h / -20 °C

With boron trifluoride diethyl etherate; caesium carbonate; In dichloromethane;
DOI:10.1002/anie.200460348