C₅₃H₅₄N₄O₃

Base Information

• Chemical Name: C₅₃H₅₄N₄O₃
• CAS No.: 1428428-02-7
• Molecular Formula: C₅₃H₅₄N₄O₃
• Molecular Weight: 795.037
• Mol file: 1428428-02-7.mol

Synonyms:C₅₃H₅₄N₄O₃

Chemical Property of C₅₃H₅₄N₄O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₃H₅₄N₄O₃

There total 18 articles about C₅₃H₅₄N₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

C58H60N4O4 (1428428-01-6) → C53H54N4O3 (1428428-02-7)

Guidance literature:

C₅₈H₆₀N₄O₄; With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); In toluene; for 2h; Reflux; Inert atmosphere;

With 2,6-dimethylpyridine; tert.-butylhydroperoxide; sodium periodate; osmium(VIII) oxide; In 1,4-dioxane; water; tert-butyl alcohol; at 20 ℃; for 5h;

With potassium carbonate; In methanol; at 0 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ol400469w

Reference yield:

3-(1H-1-triphenylmethylimidazol-4-yl)propanoic acid (160446-35-5) → C53H54N4O3 (1428428-02-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; pivaloyl chloride / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

1.2: 0.5 h / 0 - 20 °C / Inert atmosphere

2.1: (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II) / toluene / 2 h / Reflux; Inert atmosphere

2.2: 5 h / 20 °C

2.3: 4 h / 0 °C / Inert atmosphere

With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); pivaloyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene;

DOI:10.1021/ol400469w

Reference yield:

C34H39NO3Si → C53H54N4O3 (1428428-02-7)

Guidance literature:

Multi-step reaction with 13 steps

1.1: Dess-Martin periodane / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

2.1: tetrahydrofuran / 12 h / Inert atmosphere; Reflux

3.1: lithium borohydride / ethanol / 4 h / Inert atmosphere

4.1: palladium 10% on activated carbon; ammonium formate / methanol / 12.5 h / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / Inert atmosphere

6.1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran; mineral oil / 2 h / 0 - 60 °C / Inert atmosphere

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / Inert atmosphere

8.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere

9.1: copper(II) sulfate / toluene / 16 h / 20 °C / Inert atmosphere

10.1: N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran; chlorobenzene / 0.5 h / 20 - 110 °C / Inert atmosphere

11.1: hydrogenchloride / Inert atmosphere

12.1: N-ethyl-N,N-diisopropylamine; pivaloyl chloride / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

12.2: 0.5 h / 0 - 20 °C / Inert atmosphere

13.1: (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II) / toluene / 2 h / Reflux; Inert atmosphere

13.2: 5 h / 20 °C

13.3: 4 h / 0 °C / Inert atmosphere

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium borohydride; (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); palladium 10% on activated carbon; tetrabutyl ammonium fluoride; ammonium formate; pivaloyl chloride; sodium hydride; Dess-Martin periodane; copper(II) sulfate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; chlorobenzene; toluene; mineral oil; 10.1: |Grignard Reaction;

DOI:10.1021/ol400469w

upstream raw materials:

3-(1H-1-triphenylmethylimidazol-4-yl)propanoic acid

C₃₃H₄₀N₂O₃

(+)-(1R,5S)-ethyl 2-oxo-3-oxabicyclo[3.1.0]hexane-1-carboxylate

C₃₆H₄₁NO₄Si

Downstream raw materials:

C₆₄H₇₃N₇O₆