(E)-methyl 3-(4-{(R)-hydroxy[(S)-2-oxocyclopentyl]methyl}phenyl)acrylate

Base Information

Chemical Name:(E)-methyl 3-(4-{(R)-hydroxy[(S)-2-oxocyclopentyl]methyl}phenyl)acrylate
CAS No.:1380048-92-9
Molecular Formula:C₁₆H₁₈O₄
Molecular Weight:274.317
Hs Code.:

Synonyms:(E)-methyl 3-(4-{(R)-hydroxy[(S)-2-oxocyclopentyl]methyl}phenyl)acrylate

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Chemical Property of (E)-methyl 3-(4-{(R)-hydroxy[(S)-2-oxocyclopentyl]methyl}phenyl)acrylate

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Technology Process of (E)-methyl 3-(4-{(R)-hydroxy[(S)-2-oxocyclopentyl]methyl}phenyl)acrylate

There total 2 articles about (E)-methyl 3-(4-{(R)-hydroxy[(S)-2-oxocyclopentyl]methyl}phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 7560-50-1,71093-79-3,58045-41-3
methyl (2E)-3-(4-formylphenyl)acrylate

: 120-92-3
cyclopentanone

: 1380048-92-9
(E)-methyl 3-(4-{(R)-hydroxy[(S)-2-oxocyclopentyl]methyl}phenyl)acrylate

Guidance literature:: With (2S,4R)-4-(2,2-diphenylacetoxy)pyrrolidine-2-carboxylic acid; In water; at 20 ℃; for 21h; optical yield given as %ee; stereoselective reaction;
DOI:10.1002/ejoc.201200092

Reference yield:

: 15164-44-0
p-(iodophenyl)carboxaldehyde

: 1380048-92-9
(E)-methyl 3-(4-{(R)-hydroxy[(S)-2-oxocyclopentyl]methyl}phenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate; N,N-dimethyl-formamide / water / 23 h / 90 °C

1.2: 22 h / 40 °C

2.1: (2S,4R)-4-(2,2-diphenylacetoxy)pyrrolidine-2-carboxylic acid / water / 21 h / 20 °C

With (2S,4R)-4-(2,2-diphenylacetoxy)pyrrolidine-2-carboxylic acid; sodium hydrogencarbonate; N,N-dimethyl-formamide; In water; 1.1: Heck reaction / 1.2: Baylis-Hillman reaction;
DOI:10.1002/ejoc.201200092