7-(4-chlorophenyl)-1-methyl-5,6-dihydropyradihydropyrazolo[3,4-e][1,4]diazepin-4(1H)-one

Base Information

• Chemical Name: 7-(4-chlorophenyl)-1-methyl-5,6-dihydropyradihydropyrazolo[3,4-e][1,4]diazepin-4(1H)-one
• CAS No.: 1234320-85-4
• Molecular Formula: C₁₃H₁₁ClN₄O
• Molecular Weight: 274.71

Synonyms:7-(4-chlorophenyl)-1-methyl-5,6-dihydropyradihydropyrazolo[3,4-e][1,4]diazepin-4(1H)-one

Chemical Property of 7-(4-chlorophenyl)-1-methyl-5,6-dihydropyradihydropyrazolo[3,4-e][1,4]diazepin-4(1H)-one

Chemical Property:

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Technology Process of 7-(4-chlorophenyl)-1-methyl-5,6-dihydropyradihydropyrazolo[3,4-e][1,4]diazepin-4(1H)-one

There total 2 articles about 7-(4-chlorophenyl)-1-methyl-5,6-dihydropyradihydropyrazolo[3,4-e][1,4]diazepin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-[2-(4-chlorophenyl)-2-oxoethyl]-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one (1197977-44-8) → 7-(4-chlorophenyl)-1-methyl-5,6-dihydropyradihydropyrazolo[3,4-e][1,4]diazepin-4(1H)-one (1234320-85-4)

Guidance literature:

With water; sodium hydroxide; for 5h; Heating;

DOI:10.1134/S1070428012070172

Reference yield:

p-chlorophenacyl chloride (937-20-2) → 7-(4-chlorophenyl)-1-methyl-5,6-dihydropyradihydropyrazolo[3,4-e][1,4]diazepin-4(1H)-one (1234320-85-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 7 h / Reflux

2: sodium hydroxide; water / 5 h / Heating

With water; potassium carbonate; sodium hydroxide; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1134/S1070428012070172

Reference yield: 78.0%

7-(4-chlorophenyl)-1-methyl-5,6-dihydropyradihydropyrazolo[3,4-e][1,4]diazepin-4(1H)-one (1234320-85-4) → 4-chloro-7-(4-chlorophenyl)-1-methyl-1,6-dihydropyrazolo[3,4-e][1,4]diazepine

Guidance literature:

With trichlorophosphate; In toluene; at 90 - 95 ℃; for 2h;

DOI:10.1134/S107042801510022X

upstream raw materials:

p-chlorophenacyl chloride

5-[2-(4-chlorophenyl)-2-oxoethyl]-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

Downstream raw materials:

7-(4-chlorophenyl)-1-methyl-5,6,7,8-tetrahydropyrazolo[3,4-e][1,4]diazepin-4(1H)-one

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