2-Oxazolidinone,4-methyl-4-[2-(3-methyl-2-thienyl)ethenyl]-,(4R)-(9CI)

Base Information

Chemical Name:2-Oxazolidinone,4-methyl-4-[2-(3-methyl-2-thienyl)ethenyl]-,(4R)-(9CI)
CAS No.:827344-12-7
Molecular Formula:C₁₁H₁₃NO₂S
Molecular Weight:223.296
Hs Code.:
Mol file:827344-12-7.mol

Synonyms:2-Oxazolidinone,4-methyl-4-[2-(3-methyl-2-thienyl)ethenyl]-,(4R)-(9CI)

Suppliers and Price of 2-Oxazolidinone,4-methyl-4-[2-(3-methyl-2-thienyl)ethenyl]-,(4R)-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-Oxazolidinone,4-methyl-4-[2-(3-methyl-2-thienyl)ethenyl]-,(4R)-(9CI)

Chemical Property:

PSA：66.57000
LogP:2.89700

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Oxazolidinone,4-methyl-4-[2-(3-methyl-2-thienyl)ethenyl]-,(4R)-(9CI)

There total 5 articles about 2-Oxazolidinone,4-methyl-4-[2-(3-methyl-2-thienyl)ethenyl]-,(4R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 827344-10-5
Hexanoic acid (E)-(R)-2-tert-butoxycarbonylamino-2-methyl-4-(3-methyl-thiophen-2-yl)-but-3-enyl ester

: 827344-12-7
(R)-4-Methyl-4-[(E)-2-(3-methyl-thiophen-2-yl)-vinyl]-oxazolidin-2-one

Guidance literature:: Hexanoic acid (E)-(R)-2-tert-butoxycarbonylamino-2-methyl-4-(3-methyl-thiophen-2-yl)-but-3-enyl ester; With sodium hydroxide; In tetrahydrofuran; methanol; water; for 1.5h;

With potassium tert-butylate; In tetrahydrofuran; for 0.833333h;
DOI:10.1016/j.tetasy.2006.10.007

Reference yield:

: 391678-24-3
(2S)-tert-butoxycarbonylamino-3-n-hexanoyloxy-2-methyl-1-propanal

: 827344-12-7
(R)-4-Methyl-4-[(E)-2-(3-methyl-thiophen-2-yl)-vinyl]-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butoxide / tetrahydrofuran / 0.33 h / 20 °C

1.2: tetrahydrofuran / 0.5 h / cooling

2.1: NaOH / methanol; tetrahydrofuran; H₂O / 1.5 h

2.2: potassium tert-butoxide / tetrahydrofuran / 0.83 h

With sodium hydroxide; potassium tert-butylate; In tetrahydrofuran; methanol; water; 1.2: Wittig reaction;
DOI:10.1016/j.tetasy.2006.10.007

Reference yield:

: 391678-23-2
(2R)-tert-butoxycarbonylamino-3-n-hexanoyloxy-2-methyl-1-propanol

: 827344-12-7
(R)-4-Methyl-4-[(E)-2-(3-methyl-thiophen-2-yl)-vinyl]-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridinium chlorochromate; molecular sieves 4 Angstroem / CH₂Cl₂ / 2 h / 20 °C

2.1: potassium tert-butoxide / tetrahydrofuran / 0.33 h / 20 °C

2.2: tetrahydrofuran / 0.5 h / cooling

3.1: NaOH / methanol; tetrahydrofuran; H₂O / 1.5 h

3.2: potassium tert-butoxide / tetrahydrofuran / 0.83 h

With sodium hydroxide; 4 A molecular sieve; potassium tert-butylate; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; water; 2.2: Wittig reaction;
DOI:10.1016/j.tetasy.2006.10.007