(2R)-2-(BOC-amino)-N-[4-cyclohexyl-4-(t-butylcarbamoyl)piperidin-1-yl]-3-(4-chlorophenyl)propionamide

Base Information

• Chemical Name: (2R)-2-(BOC-amino)-N-[4-cyclohexyl-4-(t-butylcarbamoyl)piperidin-1-yl]-3-(4-chlorophenyl)propionamide
• CAS No.: 363192-59-0
• Molecular Formula: C₃₀H₄₆ClN₃O₄
• Molecular Weight: 548.166

Synonyms:(2R)-2-(BOC-amino)-N-[4-cyclohexyl-4-(t-butylcarbamoyl)piperidin-1-yl]-3-(4-chlorophenyl)propionamide

Chemical Property of (2R)-2-(BOC-amino)-N-[4-cyclohexyl-4-(t-butylcarbamoyl)piperidin-1-yl]-3-(4-chlorophenyl)propionamide

Chemical Property:

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Technology Process of (2R)-2-(BOC-amino)-N-[4-cyclohexyl-4-(t-butylcarbamoyl)piperidin-1-yl]-3-(4-chlorophenyl)propionamide

There total 2 articles about (2R)-2-(BOC-amino)-N-[4-cyclohexyl-4-(t-butylcarbamoyl)piperidin-1-yl]-3-(4-chlorophenyl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.9%

1-(3-dimethylaminopropyl)-1-ethylcarbodiimide hydrochloride (674791-76-5) + N-Boc-D-(4-Cl)Phe-OH (57292-44-1) → (2R)-2-(BOC-amino)-N-[4-cyclohexyl-4-(t-butylcarbamoyl)piperidin-1-yl]-3-(4-chlorophenyl)propionamide (363192-59-0)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 12h;

Reference yield:

N-Boc-D-(4-Cl)Phe-OH (57292-44-1) + N-(tert-butyl)-4-cyclohexylpiperidine-4-carboxamide (363191-02-0) → (2R)-2-(BOC-amino)-N-[4-cyclohexyl-4-(t-butylcarbamoyl)piperidin-1-yl]-3-(4-chlorophenyl)propionamide (363192-59-0)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;

DOI:10.1016/j.bmcl.2005.05.012

Reference yield:

(2R)-2-(BOC-amino)-N-[4-cyclohexyl-4-(t-butylcarbamoyl)piperidin-1-yl]-3-(4-chlorophenyl)propionamide (363192-59-0) → 1-[2-amino-3-(4-chloro-phenyl)-propionyl]-4-cyclohexyl-piperidine-4-carboxylic acid tert-butylamide; hydrochloride

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.bmcl.2005.05.012

upstream raw materials:

N-Boc-D-(4-Cl)Phe-OH

N-(tert-butyl)-4-cyclohexylpiperidine-4-carboxamide

1-(3-dimethylaminopropyl)-1-ethylcarbodiimide hydrochloride

Downstream raw materials:

{2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-chloro-benzyl)-2-oxo-ethylcarbamoyl]-indan-1-yl}-carbamic acid tert-butyl ester

{2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-chloro-benzyl)-2-oxo-ethylcarbamoyl]-1,2,3,4-tetrahydro-naphthalen-1-yl}-carbamic acid tert-butyl ester

{6-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-chloro-benzyl)-2-oxo-ethylcarbamoyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-yl}-carbamic acid tert-butyl ester

C₃₂H₅₀ClN₅O₃

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