acetic acid 4,5-diacetoxy-6-acetoxymethyl-2-{2-[2-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-imidazol-4-ylcarbamoyl]-4-nitro-pyrrol-1-yl}-tetrahydro-pyran-3-yl ester

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Chemical Name:acetic acid 4,5-diacetoxy-6-acetoxymethyl-2-{2-[2-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-imidazol-4-ylcarbamoyl]-4-nitro-pyrrol-1-yl}-tetrahydro-pyran-3-yl ester
CAS No.:664341-86-0
Molecular Formula:C₂₉H₃₉N₇O₁₃
Molecular Weight:693.668
Hs Code.:

acetic acid 4,5-diacetoxy-6-acetoxymethyl-2-{2-[2-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-imidazol-4-ylcarbamoyl]-4-nitro-pyrrol-1-yl}-tetrahydro-pyran-3-yl ester

Synonyms:acetic acid 4,5-diacetoxy-6-acetoxymethyl-2-{2-[2-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-imidazol-4-ylcarbamoyl]-4-nitro-pyrrol-1-yl}-tetrahydro-pyran-3-yl ester

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Chemical Property of acetic acid 4,5-diacetoxy-6-acetoxymethyl-2-{2-[2-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-imidazol-4-ylcarbamoyl]-4-nitro-pyrrol-1-yl}-tetrahydro-pyran-3-yl ester

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Technology Process of acetic acid 4,5-diacetoxy-6-acetoxymethyl-2-{2-[2-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-imidazol-4-ylcarbamoyl]-4-nitro-pyrrol-1-yl}-tetrahydro-pyran-3-yl ester

There total 1 articles about acetic acid 4,5-diacetoxy-6-acetoxymethyl-2-{2-[2-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-imidazol-4-ylcarbamoyl]-4-nitro-pyrrol-1-yl}-tetrahydro-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5930-93-8
4-nitropyrrole-2-carboxylic acid

: 664341-86-0
acetic acid 4,5-diacetoxy-6-acetoxymethyl-2-{2-[2-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-imidazol-4-ylcarbamoyl]-4-nitro-pyrrol-1-yl}-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 83 percent / H₂SO₄ / diethyl ether / 36 h / 20 °C

2.1: KOH / dimethylformamide / 0.5 h / 20 °C

2.2: 80 percent / 18-crown-6 / dimethylformamide / 3 h / 20 °C

3.1: 78 percent / TiCl₄ / CH₂Cl₂ / 24 h / 20 °C

4.1: 1.10 g / HOBt; EDCI / dimethylformamide / 12 h / 20 °C

With potassium hydroxide; sulfuric acid; titanium tetrachloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b306685a

Reference yield:

: 664341-86-0
acetic acid 4,5-diacetoxy-6-acetoxymethyl-2-{2-[2-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-imidazol-4-ylcarbamoyl]-4-nitro-pyrrol-1-yl}-tetrahydro-pyran-3-yl ester

: C₅₀H₇₁N₉O₁₅S₂

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / methanol / 2 h / 20 °C / 2585.81 Torr

2: 1.22 g / HOBt; EDCI / dimethylformamide / 12 h / 20 °C

3: H₂ / Pd/C / methanol / 2 h / 20 °C / 2585.81 Torr

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1039/b306685a

Reference yield:

: 664341-86-0
acetic acid 4,5-diacetoxy-6-acetoxymethyl-2-{2-[2-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-imidazol-4-ylcarbamoyl]-4-nitro-pyrrol-1-yl}-tetrahydro-pyran-3-yl ester

: C₅₀H₆₉N₉O₁₇S₂

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol / 2 h / 20 °C / 2585.81 Torr

2: 1.22 g / HOBt; EDCI / dimethylformamide / 12 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1039/b306685a