(2E)-2-(4-cyclopropylsulfonylphenyl)-2-pyrrolidin-1-ylimino-acetic acid

Base Information

• Chemical Name: (2E)-2-(4-cyclopropylsulfonylphenyl)-2-pyrrolidin-1-ylimino-acetic acid
• CAS No.: 1039020-72-8
• Molecular Formula: C₁₅H₁₈N₂O₄S
• Molecular Weight: 322.385

Synonyms:(2E)-2-(4-cyclopropylsulfonylphenyl)-2-pyrrolidin-1-ylimino-acetic acid

Chemical Property of (2E)-2-(4-cyclopropylsulfonylphenyl)-2-pyrrolidin-1-ylimino-acetic acid

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Technology Process of (2E)-2-(4-cyclopropylsulfonylphenyl)-2-pyrrolidin-1-ylimino-acetic acid

There total 2 articles about (2E)-2-(4-cyclopropylsulfonylphenyl)-2-pyrrolidin-1-ylimino-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

C16H20N2O4S (1039020-71-7) → (2E)-2-(4-cyclopropylsulfonylphenyl)-2-pyrrolidin-1-ylimino-acetic acid (1039020-72-8)

Guidance literature:

C₁₆H₂₀N₂O₄S; With water; sodium hydroxide; In methanol; at 20 ℃; for 27h; Cooling with ice;

With hydrogenchloride; water;

Reference yield: 81.0%

2-(4-cyclopropylsulfonyl-phenyl)-2-pyrrolidin-1-ylimino-acetic acid ethyl ester → (2E)-2-(4-cyclopropylsulfonylphenyl)-2-pyrrolidin-1-ylimino-acetic acid (1039020-72-8)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 20 ℃; for 4h;

DOI:10.1016/j.bmcl.2020.127249

Reference yield: 69.0%

(2E)-2-(4-cyclopropylsulfonylphenyl)-2-pyrrolidin-1-ylimino-acetic acid (1039020-72-8) + C3H4N2S*(x)ClH → (2E)-2-(4-cyclopropylsulfonylphenyl)-2-pyrrolidin-1-ylimino-N-thiazol-2-yl-acetamide

Guidance literature:

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃; for 24.5h; Cooling with ice;

DOI:10.1016/j.bmcl.2020.127249

upstream raw materials:

C₁₆H₂₀N₂O₄S

Downstream raw materials:

C₂₂H₂₃N₅O₄S₂

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