2-{(E)-3-[(1S,2S)-2-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-(3,3-dimethoxy-propyl)-butoxy]-allyl}-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

Base Information

Chemical Name:2-{(E)-3-[(1S,2S)-2-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-(3,3-dimethoxy-propyl)-butoxy]-allyl}-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane
CAS No.:910057-86-2
Molecular Formula:C₃₁H₅₅BO₇Si
Molecular Weight:578.67
Hs Code.:

Synonyms:2-{(E)-3-[(1S,2S)-2-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-(3,3-dimethoxy-propyl)-butoxy]-allyl}-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

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Chemical Property of 2-{(E)-3-[(1S,2S)-2-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-(3,3-dimethoxy-propyl)-butoxy]-allyl}-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

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Technology Process of 2-{(E)-3-[(1S,2S)-2-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-(3,3-dimethoxy-propyl)-butoxy]-allyl}-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

There total 7 articles about 2-{(E)-3-[(1S,2S)-2-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-(3,3-dimethoxy-propyl)-butoxy]-allyl}-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 910057-98-6
2-{(E)-2-[(1S,2S)-2-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-(3,3-dimethoxy-propyl)-butoxy]-vinyl}-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

: 593-71-5
Chloroiodomethane

: 910057-86-2
2-{(E)-3-[(1S,2S)-2-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-(3,3-dimethoxy-propyl)-butoxy]-allyl}-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -100 - 20 ℃; for 12h;
DOI:10.1021/ol0614471

Reference yield:

: 910057-84-0
(S)-3-Benzyloxy-tetrahydro-furan-2-ol

: 910057-86-2
2-{(E)-3-[(1S,2S)-2-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-(3,3-dimethoxy-propyl)-butoxy]-allyl}-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

Guidance literature:: Multi-step reaction with 5 steps

1.1: 82 percent / MgBr₂*Et₂O; 1,2-dibromoethane / diethyl ether; CH₂Cl₂; tetrahydrofuran / 24 h / 20 °C

2.1: 93 percent / imidazole / CH₂Cl₂; toluene / 1 h / 20 °C

3.1: KH / tetrahydrofuran / -78 - 20 °C

3.2: 72 percent / MeLi / tetrahydrofuran; diethyl ether / 1.5 h / -78 - -40 °C

4.1: 70 percent / Cp₂ZrClH / CH₂Cl₂ / 24 h / 20 °C

5.1: n-BuLi / tetrahydrofuran; hexane / 12 h / -100 - 20 °C

With 1H-imidazole; Schwartz's reagent; n-butyllithium; potassium hydride; ethylene dibromide; magnesium bromide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene;
DOI:10.1021/ol0614471

Reference yield:

: 910057-96-4
(3S,4S)-3-Benzyloxy-7,7-dimethoxy-heptane-1,4-diol

: 910057-86-2
2-{(E)-3-[(1S,2S)-2-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-(3,3-dimethoxy-propyl)-butoxy]-allyl}-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

Guidance literature:: Multi-step reaction with 4 steps

1.1: 93 percent / imidazole / CH₂Cl₂; toluene / 1 h / 20 °C

2.1: KH / tetrahydrofuran / -78 - 20 °C

2.2: 72 percent / MeLi / tetrahydrofuran; diethyl ether / 1.5 h / -78 - -40 °C

3.1: 70 percent / Cp₂ZrClH / CH₂Cl₂ / 24 h / 20 °C

4.1: n-BuLi / tetrahydrofuran; hexane / 12 h / -100 - 20 °C

With 1H-imidazole; Schwartz's reagent; n-butyllithium; potassium hydride; In tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1021/ol0614471