N-[1-(S)-benzyloxycarbonyl-3-phenylpropyl]-L-4,4'-biphenylalanine benzyl ester

Base Information

Chemical Name:N-[1-(S)-benzyloxycarbonyl-3-phenylpropyl]-L-4,4'-biphenylalanine benzyl ester
CAS No.:1345219-62-6
Molecular Formula:C₃₉H₃₇NO₄
Molecular Weight:583.727
Hs Code.:

Synonyms:N-[1-(S)-benzyloxycarbonyl-3-phenylpropyl]-L-4,4'-biphenylalanine benzyl ester

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Chemical Property of N-[1-(S)-benzyloxycarbonyl-3-phenylpropyl]-L-4,4'-biphenylalanine benzyl ester

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Technology Process of N-[1-(S)-benzyloxycarbonyl-3-phenylpropyl]-L-4,4'-biphenylalanine benzyl ester

There total 4 articles about N-[1-(S)-benzyloxycarbonyl-3-phenylpropyl]-L-4,4'-biphenylalanine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1345219-60-4
L-4,4'-biphenylalanine benzyl ester formate

: 107832-06-4
(R)-2-hydroxy-4-phenylbutyric acid benzyl ester

: 1345219-62-6
N-[1-(S)-benzyloxycarbonyl-3-phenylpropyl]-L-4,4'-biphenylalanine benzyl ester

Guidance literature:: (R)-2-hydroxy-4-phenylbutyric acid benzyl ester; With trifluoromethylsulfonic anhydride; triethylamine; In dichloromethane; at -78 ℃; for 1.5h; Inert atmosphere;

L-4,4'-biphenylalanine benzyl ester formate; In dichloromethane; at -78 - 20 ℃; for 72h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.08.064

Reference yield:

: 153037-45-7
benzyl (2S)-2-[[(tert-butoxy)carbonyl]amino]-3-(4-phenylphenyl)propanoate

: 1345219-62-6
N-[1-(S)-benzyloxycarbonyl-3-phenylpropyl]-L-4,4'-biphenylalanine benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 13 h / 20 °C

2.1: trifluoromethylsulfonic anhydride; triethylamine / dichloromethane / 1.5 h / -78 °C / Inert atmosphere

2.2: 72 h / -78 - 20 °C / Inert atmosphere

With trifluoromethylsulfonic anhydride; triethylamine; In dichloromethane;
DOI:10.1016/j.bmc.2011.08.064

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 1345219-62-6
N-[1-(S)-benzyloxycarbonyl-3-phenylpropyl]-L-4,4'-biphenylalanine benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform / 2 h / 0 - 20 °C / Inert atmosphere

2.1: 13 h / 20 °C

3.1: trifluoromethylsulfonic anhydride; triethylamine / dichloromethane / 1.5 h / -78 °C / Inert atmosphere

3.2: 72 h / -78 - 20 °C / Inert atmosphere

With dmap; trifluoromethylsulfonic anhydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; chloroform;
DOI:10.1016/j.bmc.2011.08.064