2-((2-(4-methoxybenzyl)phenyl)difluoromethyl)(2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)-tetrahydro-2H-pyran

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Chemical Name:2-((2-(4-methoxybenzyl)phenyl)difluoromethyl)(2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)-tetrahydro-2H-pyran
CAS No.:1188523-41-2
Molecular Formula:C₄₉H₄₈F₂O₆
Molecular Weight:770.913
Hs Code.:

Synonyms:2-((2-(4-methoxybenzyl)phenyl)difluoromethyl)(2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)-tetrahydro-2H-pyran

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Chemical Property of 2-((2-(4-methoxybenzyl)phenyl)difluoromethyl)(2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)-tetrahydro-2H-pyran

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Technology Process of 2-((2-(4-methoxybenzyl)phenyl)difluoromethyl)(2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)-tetrahydro-2H-pyran

There total 9 articles about 2-((2-(4-methoxybenzyl)phenyl)difluoromethyl)(2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)-tetrahydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1188523-40-1
(2-(4-methoxybenzyl)phenyl)((2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-yl)methanone

: 1188523-41-2
2-((2-(4-methoxybenzyl)phenyl)difluoromethyl)(2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)-tetrahydro-2H-pyran

Guidance literature:: With diethylamino-sulfur trifluoride; at 80 ℃; for 72h;
DOI:10.1016/j.tet.2021.131955

Reference yield:

: S-(p-tolyl) (2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-carbothioate

: 1188523-41-2
2-((2-(4-methoxybenzyl)phenyl)difluoromethyl)(2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)-tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(I) thiophene-2-carboxylate; triethyl phosphite / tert-butyl methyl ether / 24 h / 50 °C / Inert atmosphere

2: diethylamino-sulfur trifluoride / 72 h / 80 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(I) thiophene-2-carboxylate; diethylamino-sulfur trifluoride; triethyl phosphite; In tert-butyl methyl ether;
DOI:10.1016/j.tet.2021.131955

Reference yield:

: C₃₅H₃₆O₇

: 1188523-41-2
2-((2-(4-methoxybenzyl)phenyl)difluoromethyl)(2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)-tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(I) thiophene-2-carboxylate; triethyl phosphite / tert-butyl methyl ether / 24 h / 50 °C / Inert atmosphere

3: diethylamino-sulfur trifluoride / 72 h / 80 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(I) thiophene-2-carboxylate; diethylamino-sulfur trifluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethyl phosphite; In dichloromethane; tert-butyl methyl ether;
DOI:10.1016/j.tet.2021.131955