(4aR)-10bR-(4-chlorophenylsulfonyl)-7,10-difluoro-1,3,4,4a,5,10b-hexahydro-2H-[1]benzopyrano[3,4-b]pyridine-3(S)-acetonitrile

Base Information

Chemical Name:(4aR)-10bR-(4-chlorophenylsulfonyl)-7,10-difluoro-1,3,4,4a,5,10b-hexahydro-2H-[1]benzopyrano[3,4-b]pyridine-3(S)-acetonitrile
CAS No.:944949-26-2
Molecular Formula:C₂₀H₁₇ClF₂N₂O₃S
Molecular Weight:438.882
Hs Code.:

Synonyms:(4aR)-10bR-(4-chlorophenylsulfonyl)-7,10-difluoro-1,3,4,4a,5,10b-hexahydro-2H-[1]benzopyrano[3,4-b]pyridine-3(S)-acetonitrile

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Chemical Property of (4aR)-10bR-(4-chlorophenylsulfonyl)-7,10-difluoro-1,3,4,4a,5,10b-hexahydro-2H-[1]benzopyrano[3,4-b]pyridine-3(S)-acetonitrile

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Technology Process of (4aR)-10bR-(4-chlorophenylsulfonyl)-7,10-difluoro-1,3,4,4a,5,10b-hexahydro-2H-[1]benzopyrano[3,4-b]pyridine-3(S)-acetonitrile

There total 1 articles about (4aR)-10bR-(4-chlorophenylsulfonyl)-7,10-difluoro-1,3,4,4a,5,10b-hexahydro-2H-[1]benzopyrano[3,4-b]pyridine-3(S)-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 944953-05-3
3-[4-(4-chloro-benzenesulfonyl)-5,8-difluoro-chroman-3-yl-(R)-amino]-5-hydroxy-pentanenitrile

: 944949-26-2
(4aR)-10bR-(4-chlorophenylsulfonyl)-7,10-difluoro-1,3,4,4a,5,10b-hexahydro-2H-[1]benzopyrano[3,4-b]pyridine-3(S)-acetonitrile

: 944953-70-2
C₂₀H₁₇ClF₂N₂O₃S

Guidance literature:: 3-[4-(4-chloro-benzenesulfonyl)-5,8-difluoro-chroman-3-yl-(R)-amino]-5-hydroxy-pentanenitrile; With methanesulfonyl chloride; triethylamine; In dichloromethane; at 20 ℃; for 0.0833333h;

With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.166667h;

Reference yield:

: 944949-26-2
(4aR)-10bR-(4-chlorophenylsulfonyl)-7,10-difluoro-1,3,4,4a,5,10b-hexahydro-2H-[1]benzopyrano[3,4-b]pyridine-3(S)-acetonitrile

: 944949-23-9
(4aR)-10bR-[(4-chlorophenyl)sulfonyl]-7,10-difluoro-1,3,4,4a,5,10b-hexahydro-2H-[1]benzopyran[3,4-b]pyridine-3(S)-ethylamine

Guidance literature:: (4aR)-10bR-(4-chlorophenylsulfonyl)-7,10-difluoro-1,3,4,4a,5,10b-hexahydro-2H-[1]benzopyrano[3,4-b]pyridine-3(S)-acetonitrile; With dimethylsulfide borane complex; In tetrahydrofuran; at 60 ℃; for 3h;

With hydrogenchloride; water; In methanol; diethyl ether; at 20 ℃; for 1h;