N₇-cyclopropyl-N₁-(3-fluorophenyl)-2-phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole-1,7-dicarboxamide

Base Information

• Chemical Name: N₇-cyclopropyl-N₁-(3-fluorophenyl)-2-phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole-1,7-dicarboxamide
• CAS No.: 1355577-43-3
• Molecular Formula: C₂₂H₂₀FN₅O₂
• Molecular Weight: 405.432

Synonyms:N₇-cyclopropyl-N₁-(3-fluorophenyl)-2-phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole-1,7-dicarboxamide

Chemical Property of N₇-cyclopropyl-N₁-(3-fluorophenyl)-2-phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole-1,7-dicarboxamide

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Technology Process of N₇-cyclopropyl-N₁-(3-fluorophenyl)-2-phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole-1,7-dicarboxamide

There total 5 articles about N₇-cyclopropyl-N₁-(3-fluorophenyl)-2-phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole-1,7-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

C15H16N4O + 1-fluoro-3-isocyanatobenzene (404-71-7) → N7-cyclopropyl-N1-(3-fluorophenyl)-2-phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole-1,7-dicarboxamide (1355577-43-3)

Guidance literature:

In N,N-dimethyl-formamide; at 100 ℃; for 18h;

DOI:10.1016/j.ejmech.2011.11.031

Reference yield:

2-phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole-7-carboxylic acid ethyl ester (946150-83-0) → N7-cyclopropyl-N1-(3-fluorophenyl)-2-phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole-1,7-dicarboxamide (1355577-43-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / 4 h / 120 °C

2: diphenyl phosphoryl azide; triethylamine / N,N-dimethyl-formamide / 12 h / 30 - 60 °C

3: N,N-dimethyl-formamide / 18 h / 100 °C

With diphenyl phosphoryl azide; triethylamine; sodium hydroxide; In N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.11.031

Reference yield:

C12H11N3O2 (946150-84-1) → N7-cyclopropyl-N1-(3-fluorophenyl)-2-phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole-1,7-dicarboxamide (1355577-43-3)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenyl phosphoryl azide; triethylamine / N,N-dimethyl-formamide / 12 h / 30 - 60 °C

2: N,N-dimethyl-formamide / 18 h / 100 °C

With diphenyl phosphoryl azide; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.11.031

upstream raw materials:

2-phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole-7-carboxylic acid ethyl ester

C₁₂H₁₁N₃O₂

1-fluoro-3-isocyanatobenzene

2-hydrazino-1-phenylethanol

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