3-allyl-6-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-1,2,3,4-tetrahydropyridine-2-thione

Base Information

• Chemical Name: 3-allyl-6-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-1,2,3,4-tetrahydropyridine-2-thione
• CAS No.: 132351-37-2
• Molecular Formula: C₁₈H₁₇ClN₂OS
• Molecular Weight: 344.865
• Mol file: 132351-37-2.mol

Synonyms:3-allyl-6-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-1,2,3,4-tetrahydropyridine-2-thione

Chemical Property of 3-allyl-6-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-1,2,3,4-tetrahydropyridine-2-thione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-allyl-6-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-1,2,3,4-tetrahydropyridine-2-thione

There total 3 articles about 3-allyl-6-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-1,2,3,4-tetrahydropyridine-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

5-Acetyl-2-allylsulfanyl-4-(4-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3-carbonitrile (132351-35-0) → 3-allyl-6-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-1,2,3,4-tetrahydropyridine-2-thione (132351-37-2)

Guidance literature:

In dimethyl sulfoxide; at 100 ℃; for 3h;

Reference yield:

5-Acetyl-4-(4-chloro-phenyl)-2-mercapto-6-methyl-1,4-dihydro-pyridine-3-carbonitrile; compound with 4-methyl-morpholine (137551-99-6) → 3-allyl-6-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-1,2,3,4-tetrahydropyridine-2-thione (132351-37-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / ethanol / 5 h

2: 67 percent / dimethylsulfoxide / 1 h / 80 - 100 °C

In ethanol; dimethyl sulfoxide;

DOI:10.1007/BF01172273

Reference yield:

5-Acetyl-4-(4-chloro-phenyl)-2-mercapto-6-methyl-1,4-dihydro-pyridine-3-carbonitrile; compound with morpholine (103868-18-4) → 3-allyl-6-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-1,2,3,4-tetrahydropyridine-2-thione (132351-37-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / ethanol / 5 h / 25 °C

2: 67 percent / dimethylsulfoxide / 3 h / 100 °C

In ethanol; dimethyl sulfoxide;

upstream raw materials:

5-Acetyl-2-allylsulfanyl-4-(4-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3-carbonitrile

5-Acetyl-4-(4-chloro-phenyl)-2-mercapto-6-methyl-1,4-dihydro-pyridine-3-carbonitrile; compound with 4-methyl-morpholine

5-Acetyl-4-(4-chloro-phenyl)-2-mercapto-6-methyl-1,4-dihydro-pyridine-3-carbonitrile; compound with morpholine