2-[3-(4-bromophenyl)-2-oxo-7-oxa-1,4-diazaspiro[4.5]dec-3-en-1-yl]-N-[3-(trifluoromethyl)phenyl]acetamide

Base Information

• Chemical Name: 2-[3-(4-bromophenyl)-2-oxo-7-oxa-1,4-diazaspiro[4.5]dec-3-en-1-yl]-N-[3-(trifluoromethyl)phenyl]acetamide
• CAS No.: 1044506-88-8
• Molecular Formula: C₂₂H₁₉BrF₃N₃O₃
• Molecular Weight: 510.31

Synonyms:2-[3-(4-bromophenyl)-2-oxo-7-oxa-1,4-diazaspiro[4.5]dec-3-en-1-yl]-N-[3-(trifluoromethyl)phenyl]acetamide

Chemical Property of 2-[3-(4-bromophenyl)-2-oxo-7-oxa-1,4-diazaspiro[4.5]dec-3-en-1-yl]-N-[3-(trifluoromethyl)phenyl]acetamide

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Technology Process of 2-[3-(4-bromophenyl)-2-oxo-7-oxa-1,4-diazaspiro[4.5]dec-3-en-1-yl]-N-[3-(trifluoromethyl)phenyl]acetamide

There total 1 articles about 2-[3-(4-bromophenyl)-2-oxo-7-oxa-1,4-diazaspiro[4.5]dec-3-en-1-yl]-N-[3-(trifluoromethyl)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(4-bromophenyl)-7-oxa-1,4-diazaspiro[4.5]dec-3-en-2-one (1044507-01-8) + 2-bromo-N-(3′-(trifluoromethyl)phenyl)acetamide (25625-57-4) → 2-[3-(4-bromophenyl)-2-oxo-7-oxa-1,4-diazaspiro[4.5]dec-3-en-1-yl]-N-[3-(trifluoromethyl)phenyl]acetamide (1044506-88-8)

Guidance literature:

3-(4-bromophenyl)-7-oxa-1,4-diazaspiro[4.5]dec-3-en-2-one; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

2-bromo-N-(3′-(trifluoromethyl)phenyl)acetamide; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

4-methyl-1H-imidazole (822-36-6) + 2-[3-(4-bromophenyl)-2-oxo-7-oxa-1,4-diazaspiro[4.5]dec-3-en-1-yl]-N-[3-(trifluoromethyl)phenyl]acetamide (1044506-88-8) → 2-{3-[4-(5-methyl-1H-imidazol-1-yl)phenyl]-2-oxo-7-oxa-1,4-diazaspiro[4.5]dec-3-en-1-yl}-N-[3-(trifluoromethyl)phenyl]acetamide (1132817-44-7) + 2-{3-[4-(4-methyl-1H-imidazol-1-yl)phenyl]-2-oxo-7-oxa-1,4-diazaspiro[4.5]dec-3-en-1-yl}-N-[3-(trifluoromethyl)phenyl]acetamide (1132817-43-6)

Guidance literature:

With copper(l) iodide; potassium carbonate; D-histidin; In dimethyl sulfoxide; at 110 ℃; for 48h;

upstream raw materials:

3-(4-bromophenyl)-7-oxa-1,4-diazaspiro[4.5]dec-3-en-2-one

2-bromo-N-(3′-(trifluoromethyl)phenyl)acetamide

Downstream raw materials:

2-{3-[4-(5-methyl-1H-imidazol-1-yl)phenyl]-2-oxo-7-oxa-1,4-diazaspiro[4.5]dec-3-en-1-yl}-N-[3-(trifluoromethyl)phenyl]acetamide

2-{3-[4-(4-methyl-1H-imidazol-1-yl)phenyl]-2-oxo-7-oxa-1,4-diazaspiro[4.5]dec-3-en-1-yl}-N-[3-(trifluoromethyl)phenyl]acetamide

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