(1-(benzothiazol-2-yl-hydroxy-methyl)-4-{[tert-butoxycarbonylimino-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-methyl]-amino}-butyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:(1-(benzothiazol-2-yl-hydroxy-methyl)-4-{[tert-butoxycarbonylimino-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-methyl]-amino}-butyl)-carbamic acid tert-butyl ester
CAS No.:203455-56-5
Molecular Formula:C₃₃H₄₇N₅O₈S₂
Molecular Weight:705.897
Hs Code.:

(1-(benzothiazol-2-yl-hydroxy-methyl)-4-{[<i>tert</i>-butoxycarbonylimino-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-methyl]-amino}-butyl)-carbamic acid <i>tert</i>-butyl ester

Synonyms:(1-(benzothiazol-2-yl-hydroxy-methyl)-4-{[tert-butoxycarbonylimino-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-methyl]-amino}-butyl)-carbamic acid tert-butyl ester

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Chemical Property of (1-(benzothiazol-2-yl-hydroxy-methyl)-4-{[tert-butoxycarbonylimino-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-methyl]-amino}-butyl)-carbamic acid tert-butyl ester

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Technology Process of (1-(benzothiazol-2-yl-hydroxy-methyl)-4-{[tert-butoxycarbonylimino-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-methyl]-amino}-butyl)-carbamic acid tert-butyl ester

There total 1 articles about (1-(benzothiazol-2-yl-hydroxy-methyl)-4-{[tert-butoxycarbonylimino-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-methyl]-amino}-butyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 95-16-9
1,3-Benzothiazole

: 183442-80-0
((S)-4-{[[(Z)-tert-Butoxycarbonylimino]-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-methyl]-amino}-1-formyl-butyl)-carbamic acid tert-butyl ester

: 203455-56-5
(1-(benzothiazol-2-yl-hydroxy-methyl)-4-{[tert-butoxycarbonylimino-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-methyl]-amino}-butyl)-carbamic acid tert-butyl ester

Guidance literature:: With n-butyllithium; Yield given; Multistep reaction; 1.) diethyl ether, hexane, -78 deg C, 45 min, 2.) diethyl ether, hexane, -78 deg C, 1.5 h;
DOI:10.1021/jm980354p

Reference yield: 89.0%

: 203455-56-5
(1-(benzothiazol-2-yl-hydroxy-methyl)-4-{[tert-butoxycarbonylimino-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-methyl]-amino}-butyl)-carbamic acid tert-butyl ester

: 203453-39-8
N-<4-amino-5-(1,3-benzothiazol-2-yl)-5-hydroxypentyl>-N'-<(4-methoxy-2,3,6-trimethylphenyl)sulfonyl>guanidine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 1.5h; Ambient temperature;
DOI:10.1021/jm980354p

Reference yield:

: 203455-56-5
(1-(benzothiazol-2-yl-hydroxy-methyl)-4-{[tert-butoxycarbonylimino-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-methyl]-amino}-butyl)-carbamic acid tert-butyl ester

: MOL₁₄₄

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / trifluoroacetic acid / CH₂Cl₂ / 1.5 h / Ambient temperature

2: 1.) HOBt hydrate, diisopropylethylamine, EDC / 1.) THF, RT, 10 min, 2.) THF, RT, 15 h

3: 252 mg / Dess-Martin periodinane / CH₂Cl₂ / 6 h / Ambient temperature

4: 2.5 mg / 95 percent aq. trifluoroacetic acid, thioanisole / 30 h / Ambient temperature

With methyl-phenyl-thioether; benzotriazol-1-ol; Dess-Martin periodane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm980354p