(R)-ethyl 1-(4'-(1-methyl-5-((3-methylbutan-2-yloxy)carbonylamino)-1H-pyrazol-4-yl)biphenyl-4-yl)cyclopropanecarboxylate

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Chemical Name:(R)-ethyl 1-(4'-(1-methyl-5-((3-methylbutan-2-yloxy)carbonylamino)-1H-pyrazol-4-yl)biphenyl-4-yl)cyclopropanecarboxylate
CAS No.:1402466-17-4
Molecular Formula:C₂₈H₃₃N₃O₄
Molecular Weight:475.588
Hs Code.:

Synonyms:(R)-ethyl 1-(4'-(1-methyl-5-((3-methylbutan-2-yloxy)carbonylamino)-1H-pyrazol-4-yl)biphenyl-4-yl)cyclopropanecarboxylate

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Chemical Property of (R)-ethyl 1-(4'-(1-methyl-5-((3-methylbutan-2-yloxy)carbonylamino)-1H-pyrazol-4-yl)biphenyl-4-yl)cyclopropanecarboxylate

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Technology Process of (R)-ethyl 1-(4'-(1-methyl-5-((3-methylbutan-2-yloxy)carbonylamino)-1H-pyrazol-4-yl)biphenyl-4-yl)cyclopropanecarboxylate

There total 7 articles about (R)-ethyl 1-(4'-(1-methyl-5-((3-methylbutan-2-yloxy)carbonylamino)-1H-pyrazol-4-yl)biphenyl-4-yl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 598-75-4,1572-93-6
(R)-3-methyl-2-butanol

: 1380587-87-0
1-[4'-(5-amino-1-methyl-1H-pyrazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

: 503-38-8
trichloromethyl chloroformate

: 1402466-17-4
(R)-ethyl 1-(4'-(1-methyl-5-((3-methylbutan-2-yloxy)carbonylamino)-1H-pyrazol-4-yl)biphenyl-4-yl)cyclopropanecarboxylate

Guidance literature:: trichloromethyl chloroformate; With pyridine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

1-[4'-(5-amino-1-methyl-1H-pyrazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester; In dichloromethane; at 20 ℃; for 0.5h;

(R)-3-methyl-2-butanol; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 598-75-4,1572-93-6
(R)-3-methyl-2-butanol

: 32315-10-9
bis(trichloromethyl) carbonate

: 1380587-87-0
1-[4'-(5-amino-1-methyl-1H-pyrazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

: 1402466-17-4
(R)-ethyl 1-(4'-(1-methyl-5-((3-methylbutan-2-yloxy)carbonylamino)-1H-pyrazol-4-yl)biphenyl-4-yl)cyclopropanecarboxylate

Guidance literature:: bis(trichloromethyl) carbonate; 1-[4'-(5-amino-1-methyl-1H-pyrazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester; With triethylamine; In dichloromethane; toluene; at 90 ℃; for 0.166667h; Inert atmosphere;

(R)-3-methyl-2-butanol; In dichloromethane; toluene; at 85 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm301022v

Reference yield:

: 71597-85-8
(p-hydroxyphenyl)boronic acid

: 1402466-17-4
(R)-ethyl 1-(4'-(1-methyl-5-((3-methylbutan-2-yloxy)carbonylamino)-1H-pyrazol-4-yl)biphenyl-4-yl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide / Inert atmosphere

2.1: triethylamine / dichloromethane / -78 - 20 °C / Inert atmosphere

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 90 °C / Inert atmosphere

4.1: potassium phosphate; palladium diacetate; XPhos / water; toluene / 100 °C / Inert atmosphere; Sealed tube

5.1: triethylamine / dichloromethane; toluene / 0.17 h / 90 °C / Inert atmosphere

5.2: 2 h / 85 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; palladium diacetate; potassium carbonate; triethylamine; XPhos; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1.1: |Suzuki Coupling / 4.1: |Suzuki Coupling;
DOI:10.1021/jm301022v