rapamycin 42-hemisuccinate benzyl ester

Base Information

• Chemical Name: rapamycin 42-hemisuccinate benzyl ester
• CAS No.: 143136-12-3
• Molecular Formula: C₆₂H₈₉NO₁₆
• Molecular Weight: 1104.39
• Mol file: 143136-12-3.mol

Synonyms:rapamycin 42-hemisuccinate benzyl ester

Chemical Property of rapamycin 42-hemisuccinate benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rapamycin 42-hemisuccinate benzyl ester

There total 1 articles about rapamycin 42-hemisuccinate benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

benzyl 4-chloro-4-oxobutanoate (41437-17-6) + sirolimus (53123-88-9) → rapamycin 42-hemisuccinate benzyl ester (143136-12-3)

Guidance literature:

With pyridine; In dichloromethane; for 2h;

DOI:10.1016/S0040-4039(00)79954-0

Reference yield:

rapamycin 42-hemisuccinate benzyl ester (143136-12-3) → sirolimus (53123-88-9) + rapamycin 42-hemisuccinate (155589-16-5)

Guidance literature:

With sodium phosphate buffer; water; lipase; In acetonitrile; for 20h; Ambient temperature;

DOI:10.1016/S0040-4039(00)79954-0

Reference yield:

rapamycin 42-hemisuccinate benzyl ester (143136-12-3) → rapamycin 42-hemisuccinate (155589-16-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 58 percent Chromat_. / H₂O, lipase, sodium phosphate buffer, pH 7.0 / acetonitrile / 20 h / Ambient temperature

2: 98 percent / pyridine / CH₂Cl₂ / 1 h

3: 68 percent Chromat_. / H₂O, lipase, sodium phosphate buffer, pH 7.0 / acetonitrile / 20 h / Ambient temperature

With pyridine; sodium phosphate buffer; water; lipase; In dichloromethane; acetonitrile;

DOI:10.1016/S0040-4039(00)79954-0

upstream raw materials:

benzyl 4-chloro-4-oxobutanoate

sirolimus

Downstream raw materials:

sirolimus

rapamycin 42-hemisuccinate

rapamycin 42-hemisuccinate methyl ester

Refernces