Ethyl 2-(piperazin-1-yl)propanoate

Base Information

Chemical Name:Ethyl 2-(piperazin-1-yl)propanoate
CAS No.:824414-06-4
Molecular Formula:C9H18 N2 O2
Molecular Weight:186.25
Hs Code.:2933599090
European Community (EC) Number:673-812-1
DSSTox Substance ID:DTXSID90371377
Mol file:824414-06-4.mol

Synonyms:824414-06-4;Ethyl 2-(piperazin-1-yl)propanoate;2-(Piperazin-1-yl)propionic acid ethyl ester;Ethyl 2-piperazin-1-ylpropanoate;rac 2-(piperazin-1-yl)-propionic acid ethyl ester;Ethyl2-(piperazin-1-yl)propanoate;2-(PIPERAZIN-1-YL)PROPIONICACIDETHYLESTER;SCHEMBL2110264;DTXSID90371377;ethyl 2-piperazin-1-ylpropionate;LWPINFVZIFEBEG-UHFFFAOYSA-N;ZHB41406;ethyl 2-(piperazin-1-yl)propionate;AKOS009158900;PS-5076;CS-0456016;EN300-881744;A840336

Suppliers and Price of Ethyl 2-(piperazin-1-yl)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethyl2-(Piperazin-1-yl)propanoate
100mg
$ 45.00

SynQuest Laboratories
Ethyl 2-(piperazin-1-yl)propanoate
250 mg
$ 32.00

SynQuest Laboratories
Ethyl 2-(piperazin-1-yl)propanoate
1 g
$ 104.00

SynQuest Laboratories
Ethyl 2-(piperazin-1-yl)propanoate
5 g
$ 237.00

Crysdot
Ethyl2-(piperazin-1-yl)propanoate 95+%
25g
$ 450.00

Chemenu
ethyl2-(piperazin-1-yl)propanoate 95%
100g
$ 642.00

Apolloscientific
Ethyl2-(piperazin-1-yl)propanoate
1g
$ 95.00

Apolloscientific
Ethyl2-(piperazin-1-yl)propanoate
250mg
$ 29.00

Apolloscientific
Ethyl2-(piperazin-1-yl)propanoate
5g
$ 215.00

American Custom Chemicals Corporation
2-(PIPERAZIN-1-YL)PROPIONIC ACID ETHYL ESTER 95.00%
10G
$ 1316.20

Total 11 raw suppliers

Chemical Property of Ethyl 2-(piperazin-1-yl)propanoate

Chemical Property:

Vapor Pressure:0.0103mmHg at 25°C
Refractive Index:1.464
Boiling Point:263.4°C at 760 mmHg
Flash Point:113.1°C
PSA：41.57000
Density:1.022g/cm³
LogP:0.10990
Storage Temp.:2-8°C
XLogP3:0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:186.136827821
Heavy Atom Count:13
Complexity:167

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-(Piperazin-1-yl)propanoate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(C)N1CCNCC1

Technology Process of Ethyl 2-(piperazin-1-yl)propanoate

There total 2 articles about Ethyl 2-(piperazin-1-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 886448-02-8
ethyl 2-(4-tert-butoxycarbonyl-1-piperazinyl)propionate

: 824414-06-4
1-(ethoxycarbonyl-ethyl)piperazine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 1h;
DOI:10.1016/j.bmc.2005.11.058

Reference yield:

: 535-11-5,41978-69-2
Ethyl 2-bromopropionate

: 824414-06-4
1-(ethoxycarbonyl-ethyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / K₂CO₃ / dimethylformamide / 12 h / 20 °C

2: 44 percent / TFA / CH₂Cl₂ / 1 h

With potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.11.058

Reference yield: 58.0%

: 824414-06-4
1-(ethoxycarbonyl-ethyl)piperazine

: 40350-83-2,54631-82-2,54631-81-1
(2S,4R)-4-(benzyloxy)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

: 886447-98-9
ethyl 2-[4-[(4R)-benzyloxy-1-(tert-butoxycarbonyl)-(2S)-pyrrolidinylcarbonyl]-1-piperazinyl]propionate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1016/j.bmc.2005.11.058