C₄₇H₆₅NO₄SSi

Base Information

Chemical Name:C₄₇H₆₅NO₄SSi
CAS No.:1332757-68-2
Molecular Formula:C₄₇H₆₅NO₄SSi
Molecular Weight:768.189
Hs Code.:

C<sub>47</sub>H<sub>65</sub>NO<sub>4</sub>SSi

Synonyms:C₄₇H₆₅NO₄SSi

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Chemical Property of C₄₇H₆₅NO₄SSi

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Technology Process of C₄₇H₆₅NO₄SSi

There total 14 articles about C₄₇H₆₅NO₄SSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: (E)-(S)-4-Amino-2-methyl-5-tritylsulfanyl-pent-2-enoic acid allyl ester

: 1332757-67-1
C₁₉H₃₈O₃Si

: 1332757-68-2
C₄₇H₆₅NO₄SSi

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1016/j.tetlet.2011.05.107

Reference yield:

: (S)-4-benzyl-3-[(S)-4-(tert-butyldimethylsilanyloxy)-2-methylbutanoyl]oxazolidin-2-one

: 1332757-68-2
C₄₇H₆₅NO₄SSi

Guidance literature:: Multi-step reaction with 14 steps

1: lithium borohydride / tetrahydrofuran; methanol / 4 h / 0 °C

2: triethylamine / dichloromethane / 0.5 h / 20 °C

3: dimethyl sulfoxide / 4 h / 60 °C

4: diisobutylaluminium hydride / dichloromethane / 2 h / -78 °C

5: sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; sodium formate / water; tert-butyl alcohol / 2 h / 0 °C

6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 5 h / 0 - 20 °C

7: diethyl ether / 0.08 h / -10 °C

8: dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene / 6 h / 40 °C

9: 2,6-dimethylpyridine / dichloromethane / 3 h / 0 - 20 °C

10: methanol; toluene-4-sulfonic acid / 2 h / 20 °C

11: oxalyl dichloride; dimethyl sulfoxide / 0.5 h / -78 °C

12: toluene / 4 h / 20 °C

13: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 3 h / 20 °C

14: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

With 2,6-dimethylpyridine; methanol; lithium borohydride; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; oxalyl dichloride; lithium hydroxide monohydrate; dimethylsulfide borane complex; sodium formate; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 11: Swern oxidation / 12: Wittig reaction;
DOI:10.1016/j.tetlet.2011.05.107

Reference yield:

: 874674-84-7
(S)-N-methoxy-N-methyl-5-(tert-butyldimethylsilanyloxy)-3-methylpentanoic amide

: 1332757-68-2
C₄₇H₆₅NO₄SSi

Guidance literature:: Multi-step reaction with 8 steps

1: diethyl ether / 0.08 h / -10 °C

2: dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene / 6 h / 40 °C

3: 2,6-dimethylpyridine / dichloromethane / 3 h / 0 - 20 °C

4: methanol; toluene-4-sulfonic acid / 2 h / 20 °C

5: oxalyl dichloride; dimethyl sulfoxide / 0.5 h / -78 °C

6: toluene / 4 h / 20 °C

7: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 3 h / 20 °C

8: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

With 2,6-dimethylpyridine; methanol; oxalyl dichloride; lithium hydroxide monohydrate; dimethylsulfide borane complex; toluene-4-sulfonic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; HATU; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; toluene; 5: Swern oxidation / 6: Wittig reaction;
DOI:10.1016/j.tetlet.2011.05.107