1-(5-Bromopyridin-2-yl)butan-1-ol

Base Information

Chemical Name:1-(5-Bromopyridin-2-yl)butan-1-ol
CAS No.:823806-43-5
Molecular Formula:C₉H₁₂BrNO
Molecular Weight:230.104
Hs Code.:
DSSTox Substance ID:DTXSID10478791
Mol file:823806-43-5.mol

Synonyms:823806-43-5;1-(5-bromopyridin-2-yl)butan-1-ol;SCHEMBL11962614;DTXSID10478791;MAXSPYMZMXHXQU-UHFFFAOYSA-N;AKOS015892083;(+/-)-1-(5-bromopyridin-2-yl)butan-1-ol

Suppliers and Price of 1-(5-Bromopyridin-2-yl)butan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1-(5-BROMOPYRIDIN-2-YL)-BUTAN-1-OL 95.00%
5MG
$ 503.65

Total 7 raw suppliers

Chemical Property of 1-(5-Bromopyridin-2-yl)butan-1-ol

Chemical Property:

PSA：33.12000
LogP:2.67760
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:229.01023
Heavy Atom Count:12
Complexity:132

Purity/Quality:

99% ^*data from raw suppliers

1-(5-BROMOPYRIDIN-2-YL)-BUTAN-1-OL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCC(C1=NC=C(C=C1)Br)O

Technology Process of 1-(5-Bromopyridin-2-yl)butan-1-ol

There total 3 articles about 1-(5-Bromopyridin-2-yl)butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 624-28-2
2,5-dibromopyridine

: 123-72-8
butyraldehyde

: 823806-43-5
(+/-)-1-(5-bromopyridin-2-yl)butan-1-ol

Guidance literature:: 2,5-dibromopyridine; With n-butyllithium; In toluene; at -78 - -70 ℃; for 0.5h; Inert atmosphere;

butyraldehyde; In toluene; at -78 ℃; for 0.5h;

With ammonium chloride;

Reference yield: 69.0%

: 223463-13-6
2-iodo-5-bromopyridine

: 123-72-8
butyraldehyde

: 823806-43-5
(+/-)-1-(5-bromopyridin-2-yl)butan-1-ol

Guidance literature:: 2-iodo-5-bromopyridine; With isopropylmagnesium chloride; In tetrahydrofuran; at -15 - 0 ℃; for 1h;

butyraldehyde; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1021/ol0400589

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 823806-43-5
(+/-)-1-(5-bromopyridin-2-yl)butan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 85 percent / NaI; AcCl / acetonitrile / 3 h / Heating

2.1: iPrMgCl / tetrahydrofuran / 1 h / -15 - 0 °C

2.2: 69 percent / tetrahydrofuran / 3 h / 20 °C

With isopropylmagnesium chloride; acetyl chloride; sodium iodide; In tetrahydrofuran; acetonitrile;
DOI:10.1021/ol0400589