(R)-[2-(4'-bromophenoxy)-3-(4''-methoxybenzyloxy)propoxy]tertbutyldiphenylsilane

Base Information

Chemical Name:(R)-[2-(4'-bromophenoxy)-3-(4''-methoxybenzyloxy)propoxy]tertbutyldiphenylsilane
CAS No.:1589000-82-7
Molecular Formula:C₃₃H₃₇BrO₄Si
Molecular Weight:605.644
Hs Code.:

Synonyms:(R)-[2-(4'-bromophenoxy)-3-(4''-methoxybenzyloxy)propoxy]tertbutyldiphenylsilane

Suppliers and Price of (R)-[2-(4'-bromophenoxy)-3-(4''-methoxybenzyloxy)propoxy]tertbutyldiphenylsilane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-[2-(4'-bromophenoxy)-3-(4''-methoxybenzyloxy)propoxy]tertbutyldiphenylsilane

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Technology Process of (R)-[2-(4'-bromophenoxy)-3-(4''-methoxybenzyloxy)propoxy]tertbutyldiphenylsilane

There total 3 articles about (R)-[2-(4'-bromophenoxy)-3-(4''-methoxybenzyloxy)propoxy]tertbutyldiphenylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 106-41-2
4-bromo-phenol

: 1065484-10-7
(S)-1-(tert-butyldiphenylsilyloxy)-3-(4'-methoxybenzyloxy)propan-2-ol

: 1589000-82-7
(R)-[2-(4'-bromophenoxy)-3-(4''-methoxybenzyloxy)propoxy]tertbutyldiphenylsilane

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; at 0 - 20 ℃; for 20h; Inert atmosphere;
DOI:10.1002/ejoc.201301363

Reference yield:

: 109786-74-5
(R)-3-(4-methoxybenzyloxy)propane-1,2-diol

: 1589000-82-7
(R)-[2-(4'-bromophenoxy)-3-(4''-methoxybenzyloxy)propoxy]tertbutyldiphenylsilane

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / 20 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; di-isopropyl azodicarboxylate; triphenylphosphine; In N,N-dimethyl-formamide; 2: |Mitsunobu Displacement;
DOI:10.1002/ejoc.201301363

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1589000-82-7
(R)-[2-(4'-bromophenoxy)-3-(4''-methoxybenzyloxy)propoxy]tertbutyldiphenylsilane

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: 48 h / 20 °C / Inert atmosphere

2.1: hydrogenchloride / water; tetrahydrofuran / 23 h / 20 °C / Inert atmosphere

3.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / 20 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; hydrogenchloride; di-isopropyl azodicarboxylate; potassium tert-butylate; triphenylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide; 4.1: |Mitsunobu Displacement;
DOI:10.1002/ejoc.201301363