4-(2-fluoro-4-methoxyphenyl)-2-(2-methoxyphenyl)-5-(pyridin-3-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6 (2H,5H)-dione

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Chemical Name:4-(2-fluoro-4-methoxyphenyl)-2-(2-methoxyphenyl)-5-(pyridin-3-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6 (2H,5H)-dione
CAS No.:1434159-16-6
Molecular Formula:C₂₆H₂₁FN₄O₄
Molecular Weight:472.476
Hs Code.:

Synonyms:4-(2-fluoro-4-methoxyphenyl)-2-(2-methoxyphenyl)-5-(pyridin-3-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6 (2H,5H)-dione

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Chemical Property of 4-(2-fluoro-4-methoxyphenyl)-2-(2-methoxyphenyl)-5-(pyridin-3-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6 (2H,5H)-dione

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Technology Process of 4-(2-fluoro-4-methoxyphenyl)-2-(2-methoxyphenyl)-5-(pyridin-3-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6 (2H,5H)-dione

There total 6 articles about 4-(2-fluoro-4-methoxyphenyl)-2-(2-methoxyphenyl)-5-(pyridin-3-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6 (2H,5H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1434169-26-2
methyl [(4E)-4-{(2-fluoro-4-methoxyphenyl)[(pyridin-3-ylmethyl)amino] methylidene}-1-(2-methoxyphenyl)-5-oxo-4, 5-dihydro-1H-pyrazol-3-yl]acetate

: 1434159-16-6
4-(2-fluoro-4-methoxyphenyl)-2-(2-methoxyphenyl)-5-(pyridin-3-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6 (2H,5H)-dione

Guidance literature:: With sodium methylate; In methanol; at 20 ℃; for 1h;

Reference yield:

: 1830-54-2
3-oxopentanedioic acid dimethyl ester

: 1434159-16-6
4-(2-fluoro-4-methoxyphenyl)-2-(2-methoxyphenyl)-5-(pyridin-3-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6 (2H,5H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / 1 h / Inert atmosphere; Reflux

2: calcium hydroxide / 1,4-dioxane / 4 h / 110 °C / Inert atmosphere

3: titanium tetrachloride; acetic acid / toluene / 1.5 h / 90 - 100 °C / Inert atmosphere

4: sodium methylate / methanol / 1 h / 20 °C

With sodium methylate; titanium tetrachloride; acetic acid; calcium hydroxide; In 1,4-dioxane; methanol; toluene;

Reference yield:

: 1158435-45-0
methyl [5-hydroxy-1-(2-methoxyphenyl)-1H-pyrazol-3-yl]acetate

: 1434159-16-6
4-(2-fluoro-4-methoxyphenyl)-2-(2-methoxyphenyl)-5-(pyridin-3-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6 (2H,5H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: calcium hydroxide / 1,4-dioxane / 4 h / 110 °C / Inert atmosphere

2: titanium tetrachloride; acetic acid / toluene / 1.5 h / 90 - 100 °C / Inert atmosphere

3: sodium methylate / methanol / 1 h / 20 °C

With sodium methylate; titanium tetrachloride; acetic acid; calcium hydroxide; In 1,4-dioxane; methanol; toluene;