phthalidyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride

Base Information

• Chemical Name: phthalidyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride
• CAS No.: 100165-52-4
• Molecular Formula: C₁₆H₁₉NO₄*ClH
• Molecular Weight: 325.792
• Mol file: 100165-52-4.mol

Synonyms:phthalidyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride

Chemical Property of phthalidyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phthalidyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride

There total 5 articles about phthalidyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Bromophthalide (6940-49-4) + 4-(N-tert-butyloxycarbonylaminomethyl)-cyclohexane-1-carboxylic acid (162046-58-4) → phthalidyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride (100165-52-4)

Guidance literature:

With hydrogenchloride; In N-methyl-acetamide; methanol; water; ethyl acetate; triethylamine;

Reference yield:

4-(tert-Butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid 3-oxo-1,3-dihydro-isobenzofuran-1-yl ester → phthalidyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride (100165-52-4)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 0 ℃; for 3h; Yield given;

DOI:10.1021/jm00154a004

Reference yield:

3-chloro-1(3H)-isobenzofuranone (6295-21-2) → phthalidyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride (100165-52-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) tetrabutylammonium hydrogen sulfate (QHSO₄), 2 M aq. NaOH / 2.) trichloroethylene, reflux, 3 h

2: HCl(g) / ethyl acetate / 3 h / 0 °C

With hydrogenchloride; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In ethyl acetate;

DOI:10.1021/jm00154a004

upstream raw materials:

3-chloro-1(3H)-isobenzofuranone

trans-4-aminomethyl-cyclohexyl-carboxylic acid

trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid

3-Bromophthalide

Refernces

• 1、 -. "Antifibrinolytically active derivatives of tranexamic acid". . . Retrieved 2008/06/13.