5-[3,5-bis(trifluoromethyl)benzyl]-7-(2-fluorophenyl)-6-oxo-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine

Base Information

Chemical Name:5-[3,5-bis(trifluoromethyl)benzyl]-7-(2-fluorophenyl)-6-oxo-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine
CAS No.:544671-83-2
Molecular Formula:C₂₄H₁₇F₇N₂O₂
Molecular Weight:498.4
Hs Code.:

Synonyms:5-[3,5-bis(trifluoromethyl)benzyl]-7-(2-fluorophenyl)-6-oxo-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[3,5-bis(trifluoromethyl)benzyl]-7-(2-fluorophenyl)-6-oxo-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine

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Technology Process of 5-[3,5-bis(trifluoromethyl)benzyl]-7-(2-fluorophenyl)-6-oxo-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine

There total 6 articles about 5-[3,5-bis(trifluoromethyl)benzyl]-7-(2-fluorophenyl)-6-oxo-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1993-03-9
o-fluorophenylboronic acid

: 544671-80-9
5-[3,5-bis(trifluoromethyl)benzyl]-7-iodo-3,4,5,6-tetrahydro-2H-pyrido[2,3-b]-1,5-oxazocin-6-one

: 544671-83-2
5-[3,5-bis(trifluoromethyl)benzyl]-7-(2-fluorophenyl)-6-oxo-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; toluene; for 7h; Heating;
DOI:10.1016/j.tetlet.2004.09.104

Reference yield: 77.0%

: 544671-83-2
5-[3,5-bis(trifluoromethyl)benzyl]-7-(2-fluorophenyl)-6-oxo-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine

Guidance literature:

Reference yield:

: 78607-36-0
2-chloro-3-iodopyridine

: 544671-83-2
5-[3,5-bis(trifluoromethyl)benzyl]-7-(2-fluorophenyl)-6-oxo-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine

Guidance literature:: Multi-step reaction with 5 steps

1.1: LDA / tetrahydrofuran / 5 h / -78 °C

1.2: tetrahydrofuran / 1 h

1.3: 81 percent / hydrochloric acid / 1 h / 20 °C

2.1: thionyl chloride / dimethylformamide / 3 h / Heating

3.1: tetrahydrofuran / 3 h / 0 - 20 °C

4.1: K₂CO₃ / ethanol / 6 h / Heating

5.1: 77 percent / Na₂CO₃; Pd(PPh₃)4 / toluene; dioxane / 7 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sodium carbonate; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; toluene; 5.1: Suzuki coupling;
DOI:10.1016/j.tetlet.2004.09.104