6-bromo-3-methoxy-4-phenyl-6-(phenylmethyl)-2H-pyran-2,5(6H)-dione

Base Information

• Chemical Name: 6-bromo-3-methoxy-4-phenyl-6-(phenylmethyl)-2H-pyran-2,5(6H)-dione
• CAS No.: 131146-47-9
• Molecular Formula: C₁₉H₁₅BrO₄
• Molecular Weight: 387.23
• Mol file: 131146-47-9.mol

Synonyms:6-bromo-3-methoxy-4-phenyl-6-(phenylmethyl)-2H-pyran-2,5(6H)-dione

Chemical Property of 6-bromo-3-methoxy-4-phenyl-6-(phenylmethyl)-2H-pyran-2,5(6H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-bromo-3-methoxy-4-phenyl-6-(phenylmethyl)-2H-pyran-2,5(6H)-dione

There total 9 articles about 6-bromo-3-methoxy-4-phenyl-6-(phenylmethyl)-2H-pyran-2,5(6H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-methoxy-4-phenyl-6-(phenylmethyl)-2H-pyran-2,5(6H)-dione (131146-44-6) → 6-bromo-3-methoxy-4-phenyl-6-(phenylmethyl)-2H-pyran-2,5(6H)-dione (131146-47-9)

Guidance literature:

With bromine; In acetic acid; for 3h; Ambient temperature;

Reference yield: 35.0%

3-methoxy-4-phenyl-6-(phenylmethyl)-2H-pyran-2,5(6H)-dione (131146-44-6) → 3-methoxy-4-phenyl-6-(phenylmethylene)-2H-pyran-2,5(6H)-dione (131146-48-0) + 6-bromo-3-methoxy-4-phenyl-6-(phenylmethyl)-2H-pyran-2,5(6H)-dione (131146-47-9)

Guidance literature:

With N-Bromosuccinimide; In tetrachloromethane; for 0.116667h; Heating; irradiation;

Reference yield:

3-hydroxy-1,4-diphenyl-2-butanone (6838-54-6) → 6-bromo-3-methoxy-4-phenyl-6-(phenylmethyl)-2H-pyran-2,5(6H)-dione (131146-47-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 68 percent / triethylamine / tetrahydrofuran / 0.5 h / 25 °C

2: 91 percent / 1,5-diazabicyclo<5.4.0>undec-5-ene / dimethylformamide / 3 h / -15 °C

3: 82 percent / diethyl ether / 0.25 h / 0 °C

4: 90 percent / bromine / acetic acid / 3 h / Ambient temperature

With bromine; triethylamine; 1,5-Diazabicyclo[5.4.0]undec-5-ene; In tetrahydrofuran; diethyl ether; acetic acid; N,N-dimethyl-formamide;

upstream raw materials:

3-methoxy-4-phenyl-6-(phenylmethyl)-2H-pyran-2,5(6H)-dione

3-hydroxy-1,4-diphenyl-2-butanone

phenylmagnesium bromide

phenylacetaldehyde

Downstream raw materials:

3-methoxy-4-phenyl-6-(phenylmethylene)-2H-pyran-2,5(6H)-dione

6-benzylidene-3-methoxy-4-phenylpyran-2,5-dione

5-hydroxy-3,4,7-triphenylbenzofuran-2,6-dione

6-benzylidene-3-hydroxy-4-phenyl-pyran-2,5-dione