5-(4-amino-2-cyclopropyl-5-methyl-2H-imidazol-2-yl)-2'-chloro-5'-methoxybiphenyl-2-ol

Base Information

Chemical Name:5-(4-amino-2-cyclopropyl-5-methyl-2H-imidazol-2-yl)-2'-chloro-5'-methoxybiphenyl-2-ol
CAS No.:1260215-96-0
Molecular Formula:C₂₀H₂₀ClN₃O₂
Molecular Weight:369.851
Hs Code.:

Synonyms:5-(4-amino-2-cyclopropyl-5-methyl-2H-imidazol-2-yl)-2'-chloro-5'-methoxybiphenyl-2-ol

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Chemical Property of 5-(4-amino-2-cyclopropyl-5-methyl-2H-imidazol-2-yl)-2'-chloro-5'-methoxybiphenyl-2-ol

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Technology Process of 5-(4-amino-2-cyclopropyl-5-methyl-2H-imidazol-2-yl)-2'-chloro-5'-methoxybiphenyl-2-ol

There total 5 articles about 5-(4-amino-2-cyclopropyl-5-methyl-2H-imidazol-2-yl)-2'-chloro-5'-methoxybiphenyl-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 1260215-37-9
4-(4-amino-2-cyclopropyl-5-methyl-2H-imidazol-2-yl)-2-bromophenol

: 89694-46-2
2-chloro-5-methoxyphenylboronic acid

: 1260215-96-0
5-(4-amino-2-cyclopropyl-5-methyl-2H-imidazol-2-yl)-2'-chloro-5'-methoxybiphenyl-2-ol

Guidance literature:: With caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; ethanol; water; at 150 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 117572-79-9
3-bromo-4-methoxybenzonitrile

: 1260215-96-0
5-(4-amino-2-cyclopropyl-5-methyl-2H-imidazol-2-yl)-2'-chloro-5'-methoxybiphenyl-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: copper(I) bromide / tetrahydrofuran / 3 h / 40 °C / Inert atmosphere

2: methanol / 4 h / 50 °C

3: ammonia / methanol / 1 h / 110 °C / Microwave irradiation

4: boron tribromide / dichloromethane / 20 °C

5: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; ethanol; water / 0.5 h / 150 °C / Microwave irradiation

With ammonia; boron tribromide; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(I) bromide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water;

Reference yield:

: 1260215-35-7
2-(3-bromo-4-methoxyphenyl)-2-cyclopropyl-4-methyl-1H-imidazole-5(2H)-thione

: 1260215-96-0
5-(4-amino-2-cyclopropyl-5-methyl-2H-imidazol-2-yl)-2'-chloro-5'-methoxybiphenyl-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia / methanol / 1 h / 110 °C / Microwave irradiation

2: boron tribromide / dichloromethane / 20 °C

3: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; ethanol; water / 0.5 h / 150 °C / Microwave irradiation

With ammonia; boron tribromide; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water;