(3S,4S)-N-butyl-3-isopropyl-4-(4-methylphenyl)-2-oxo-4-(propanamido)butanamide

Base Information

Chemical Name:(3S,4S)-N-butyl-3-isopropyl-4-(4-methylphenyl)-2-oxo-4-(propanamido)butanamide
CAS No.:1448796-66-4
Molecular Formula:C₂₁H₃₂N₂O₃
Molecular Weight:360.497
Hs Code.:

Synonyms:(3S,4S)-N-butyl-3-isopropyl-4-(4-methylphenyl)-2-oxo-4-(propanamido)butanamide

Suppliers and Price of (3S,4S)-N-butyl-3-isopropyl-4-(4-methylphenyl)-2-oxo-4-(propanamido)butanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,4S)-N-butyl-3-isopropyl-4-(4-methylphenyl)-2-oxo-4-(propanamido)butanamide

Chemical Property:

Purity/Quality:

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Technology Process of (3S,4S)-N-butyl-3-isopropyl-4-(4-methylphenyl)-2-oxo-4-(propanamido)butanamide

There total 5 articles about (3S,4S)-N-butyl-3-isopropyl-4-(4-methylphenyl)-2-oxo-4-(propanamido)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₃₄N₂O₃

: 1448796-66-4
(3S,4S)-N-butyl-3-isopropyl-4-(4-methylphenyl)-2-oxo-4-(propanamido)butanamide

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 25 ℃; for 14h;
DOI:10.1002/chem.201300023

Reference yield:

: 365441-83-4
tert-butyl (p-tolyl(tosyl)methyl)carbamate

: 1448796-66-4
(3S,4S)-N-butyl-3-isopropyl-4-(4-methylphenyl)-2-oxo-4-(propanamido)butanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / tetrahydrofuran / 3 h / 50 °C

2.1: L-proline / acetonitrile / 18 h / 0 °C

3.1: dichloromethane / 20 h / 25 °C

4.1: trifluoroacetic acid / dichloromethane / 3 h / 25 °C

4.2: 14 h / 25 °C

5.1: Dess-Martin periodane / dichloromethane / 14 h / 25 °C

With caesium carbonate; Dess-Martin periodane; trifluoroacetic acid; L-proline; In tetrahydrofuran; dichloromethane; acetonitrile; 2.1: |Mannich Aminomethylation / 3.1: |Passerini Condensation;
DOI:10.1002/chem.201300023

Reference yield:

: 479423-39-7
4-methylbenzaldehyde N-(tert-butoxycarbonyl)imine

: 1448796-66-4
(3S,4S)-N-butyl-3-isopropyl-4-(4-methylphenyl)-2-oxo-4-(propanamido)butanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: L-proline / acetonitrile / 18 h / 0 °C

2.1: dichloromethane / 20 h / 25 °C

3.1: trifluoroacetic acid / dichloromethane / 3 h / 25 °C

3.2: 14 h / 25 °C

4.1: Dess-Martin periodane / dichloromethane / 14 h / 25 °C

With Dess-Martin periodane; trifluoroacetic acid; L-proline; In dichloromethane; acetonitrile; 1.1: |Mannich Aminomethylation / 2.1: |Passerini Condensation;
DOI:10.1002/chem.201300023