((R)-3-amino-pyrrolidin-1-yl)-[6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]-pyridin-4-yl]-methanone hydrochloride salt

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Chemical Name:((R)-3-amino-pyrrolidin-1-yl)-[6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]-pyridin-4-yl]-methanone hydrochloride salt
CAS No.:1431977-27-3
Molecular Formula:C₁₇H₁₇N₅O₂*ClH
Molecular Weight:359.815
Hs Code.:

Synonyms:((R)-3-amino-pyrrolidin-1-yl)-[6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]-pyridin-4-yl]-methanone hydrochloride salt

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Chemical Property of ((R)-3-amino-pyrrolidin-1-yl)-[6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]-pyridin-4-yl]-methanone hydrochloride salt

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Technology Process of ((R)-3-amino-pyrrolidin-1-yl)-[6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]-pyridin-4-yl]-methanone hydrochloride salt

There total 8 articles about ((R)-3-amino-pyrrolidin-1-yl)-[6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]-pyridin-4-yl]-methanone hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1431978-10-7
{(R)-1-[6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-pyrrolidin-3-yl} carbamic acid tert-butyl ester

: 1431977-27-3
((R)-3-amino-pyrrolidin-1-yl)-[6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]-pyridin-4-yl]-methanone hydrochloride salt

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

Reference yield:

: 1246553-04-7
6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

: 1431977-27-3
((R)-3-amino-pyrrolidin-1-yl)-[6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]-pyridin-4-yl]-methanone hydrochloride salt

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methyl-morpholine; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C

2: hydrogenchloride / 1,4-dioxane / 20 °C

With 4-methyl-morpholine; hydrogenchloride; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1431977-27-3
((R)-3-amino-pyrrolidin-1-yl)-[6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]-pyridin-4-yl]-methanone hydrochloride salt

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / methanol / 15 h / 75 °C

2: lithium hydroxide; water / methanol

3: 4-methyl-morpholine; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C

4: hydrogenchloride / 1,4-dioxane / 20 °C

With 4-methyl-morpholine; hydrogenchloride; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; water; acetic acid; lithium hydroxide; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;