(methyl 2,3,4-tri-O-benzyl-β-D-glucopyranosid-6-yl) 2-cyanoethyl 1-O-(2-azido-4,6-O-benzylidene-2-deoxy-3-O-methyl-β-D-galactopyranosyl) 2,3,4-tri-O-benzyl-L-ribityl-5-phosphate

Base Information

Chemical Name:(methyl 2,3,4-tri-O-benzyl-β-D-glucopyranosid-6-yl) 2-cyanoethyl 1-O-(2-azido-4,6-O-benzylidene-2-deoxy-3-O-methyl-β-D-galactopyranosyl) 2,3,4-tri-O-benzyl-L-ribityl-5-phosphate
CAS No.:230620-44-7
Molecular Formula:C₇₁H₇₉N₄O₁₇P
Molecular Weight:1291.4
Hs Code.:

(methyl 2,3,4-tri-O-benzyl-β-D-glucopyranosid-6-yl) 2-cyanoethyl 1-O-(2-azido-4,6-O-benzylidene-2-deoxy-3-O-methyl-β-D-galactopyranosyl) 2,3,4-tri-O-benzyl-L-ribityl-5-phosphate

Synonyms:(methyl 2,3,4-tri-O-benzyl-β-D-glucopyranosid-6-yl) 2-cyanoethyl 1-O-(2-azido-4,6-O-benzylidene-2-deoxy-3-O-methyl-β-D-galactopyranosyl) 2,3,4-tri-O-benzyl-L-ribityl-5-phosphate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (methyl 2,3,4-tri-O-benzyl-β-D-glucopyranosid-6-yl) 2-cyanoethyl 1-O-(2-azido-4,6-O-benzylidene-2-deoxy-3-O-methyl-β-D-galactopyranosyl) 2,3,4-tri-O-benzyl-L-ribityl-5-phosphate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (methyl 2,3,4-tri-O-benzyl-β-D-glucopyranosid-6-yl) 2-cyanoethyl 1-O-(2-azido-4,6-O-benzylidene-2-deoxy-3-O-methyl-β-D-galactopyranosyl) 2,3,4-tri-O-benzyl-L-ribityl-5-phosphate

There total 18 articles about (methyl 2,3,4-tri-O-benzyl-β-D-glucopyranosid-6-yl) 2-cyanoethyl 1-O-(2-azido-4,6-O-benzylidene-2-deoxy-3-O-methyl-β-D-galactopyranosyl) 2,3,4-tri-O-benzyl-L-ribityl-5-phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: phosphorous acid 5-(7-azido-8-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-2,3,4-tris-benzyloxy-pentyl ester 2-cyano-ethyl ester 3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester

: 230620-44-7
(methyl 2,3,4-tri-O-benzyl-β-D-glucopyranosid-6-yl) 2-cyanoethyl 1-O-(2-azido-4,6-O-benzylidene-2-deoxy-3-O-methyl-β-D-galactopyranosyl) 2,3,4-tri-O-benzyl-L-ribityl-5-phosphate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile; at 0 ℃; for 0.333333h;
DOI:10.1139/v99-056

Reference yield:

: 111549-97-4
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol

: 230620-44-7
(methyl 2,3,4-tri-O-benzyl-β-D-glucopyranosid-6-yl) 2-cyanoethyl 1-O-(2-azido-4,6-O-benzylidene-2-deoxy-3-O-methyl-β-D-galactopyranosyl) 2,3,4-tri-O-benzyl-L-ribityl-5-phosphate

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / dimethylformamide / 0.33 h / 0 °C

1.2: 89 percent / dimethylformamide / 4 h / 20 °C

2.1: 69 percent / 10 percent Pd/C / methanol; H₂O / 10 h / 60 °C

3.1: 16 percent / TMSOTf / acetonitrile / 0.67 h / -50 °C

4.1: tetrazole / acetonitrile / 0.67 h

5.1: 84 percent / MCPBA / acetonitrile; CH₂Cl₂ / 0.33 h / 0 °C

With 1H-tetrazole; palladium on activated charcoal; trimethylsilyl trifluoromethanesulfonate; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 1.1: Metallation / 1.2: Alkylation / 2.1: deprotection / 3.1: glycosylation / 4.1: glycosylation / 5.1: Oxidation;
DOI:10.1139/v99-056

Reference yield:

: 118964-49-1
5-O-allyl 2,3,4-tri-O-benzyl-D-ribose diethyl dithioacetal

: 230620-44-7
(methyl 2,3,4-tri-O-benzyl-β-D-glucopyranosid-6-yl) 2-cyanoethyl 1-O-(2-azido-4,6-O-benzylidene-2-deoxy-3-O-methyl-β-D-galactopyranosyl) 2,3,4-tri-O-benzyl-L-ribityl-5-phosphate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 86 percent / aq. HgCl₂; CaCO₃ / acetonitrile / 1 h / 20 °C

2.1: 90 percent / NaBH₄ / methanol; H₂O / 10 h

3.1: NaH / dimethylformamide / 0.33 h / 0 °C

3.2: 89 percent / dimethylformamide / 4 h / 20 °C

4.1: 69 percent / 10 percent Pd/C / methanol; H₂O / 10 h / 60 °C

5.1: 16 percent / TMSOTf / acetonitrile / 0.67 h / -50 °C

6.1: tetrazole / acetonitrile / 0.67 h

7.1: 84 percent / MCPBA / acetonitrile; CH₂Cl₂ / 0.33 h / 0 °C

With 1H-tetrazole; sodium tetrahydroborate; palladium on activated charcoal; trimethylsilyl trifluoromethanesulfonate; sodium hydride; 3-chloro-benzenecarboperoxoic acid; calcium carbonate; mercury dichloride; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 1.1: deprotection / 2.1: Reduction / 3.1: Metallation / 3.2: Alkylation / 4.1: deprotection / 5.1: glycosylation / 6.1: glycosylation / 7.1: Oxidation;
DOI:10.1139/v99-056