(E)-5,5-bis(phenylsulfonyl)-5-ethynyl-2-methyl-1-trimethylsilyl-2-pentene

Base Information

Chemical Name:(E)-5,5-bis(phenylsulfonyl)-5-ethynyl-2-methyl-1-trimethylsilyl-2-pentene
CAS No.:259879-43-1
Molecular Formula:C₂₄H₃₀O₄S₂Si
Molecular Weight:474.717
Hs Code.:

Synonyms:(E)-5,5-bis(phenylsulfonyl)-5-ethynyl-2-methyl-1-trimethylsilyl-2-pentene

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Chemical Property of (E)-5,5-bis(phenylsulfonyl)-5-ethynyl-2-methyl-1-trimethylsilyl-2-pentene

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Technology Process of (E)-5,5-bis(phenylsulfonyl)-5-ethynyl-2-methyl-1-trimethylsilyl-2-pentene

There total 5 articles about (E)-5,5-bis(phenylsulfonyl)-5-ethynyl-2-methyl-1-trimethylsilyl-2-pentene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 259879-66-8
(E)-5,5-bis(phenylsulfonyl)-2-methyl-1-trimethylsilyl-2-pentene

: 106-96-7
propargyl bromide

: 259879-43-1
(E)-5,5-bis(phenylsulfonyl)-5-ethynyl-2-methyl-1-trimethylsilyl-2-pentene

Guidance literature:: (E)-5,5-bis(phenylsulfonyl)-2-methyl-1-trimethylsilyl-2-pentene; With sodium hydride; In N,N-dimethyl-formamide; at 23 ℃; for 0.5h;

propargyl bromide; In N,N-dimethyl-formamide; at 23 ℃; for 17h; Further stages.;
DOI:10.1021/ja993524b

Reference yield:

: 259879-65-7
5,5-bis(phenylsulfonyl)-2-methyl-1-trifluoroacetyloxy-2-pentene

: 259879-43-1
(E)-5,5-bis(phenylsulfonyl)-5-ethynyl-2-methyl-1-trimethylsilyl-2-pentene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 76 percent / Pd₂(dba)3*dba / tetrahydrofuran / 12 h / 23 °C

2.1: NaH / dimethylformamide / 0.5 h / 23 °C

2.2: 77 mg / dimethylformamide / 17 h / 23 °C

With Pd₂(dba)4; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo025812n

Reference yield:

: 3406-02-8
bis(phenylsulfonyl)methane

: 259879-43-1
(E)-5,5-bis(phenylsulfonyl)-5-ethynyl-2-methyl-1-trimethylsilyl-2-pentene

Guidance literature:: Multi-step reaction with 4 steps

1.1: 98 percent / Pd₂(dba)3*(dba); dppe / tetrahydrofuran / 17 h / 23 °C

2.1: 83 percent / DMAP; i-PrEt₂N / CH₂Cl₂ / 2.5 h / 23 °C

3.1: 76 percent / Pd₂(dba)3*dba / tetrahydrofuran / 12 h / 23 °C

4.1: NaH / dimethylformamide / 0.5 h / 23 °C

4.2: 77 mg / dimethylformamide / 17 h / 23 °C

With dmap; Pd₂(dba)4; N,N-diethyl-N-isopropylamine; sodium hydride; 1,2-bis-(diphenylphosphino)ethane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo025812n