1-oxo-2β-[3-butanone]-3α-methyl-6β-[2-propanol formyl ester]-cyclohexane

Base Information

• Chemical Name: 1-oxo-2β-[3-butanone]-3α-methyl-6β-[2-propanol formyl ester]-cyclohexane
• CAS No.: 176022-28-9
• Molecular Formula: C₁₅H₂₄O₄
• Molecular Weight: 268.353
• Mol file: 176022-28-9.mol

Synonyms:1-oxo-2β-[3-butanone]-3α-methyl-6β-[2-propanol formyl ester]-cyclohexane

Chemical Property of 1-oxo-2β-[3-butanone]-3α-methyl-6β-[2-propanol formyl ester]-cyclohexane

Chemical Property:

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Technology Process of 1-oxo-2β-[3-butanone]-3α-methyl-6β-[2-propanol formyl ester]-cyclohexane

There total 3 articles about 1-oxo-2β-[3-butanone]-3α-methyl-6β-[2-propanol formyl ester]-cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

(+)-deoxyartemisinin (126189-95-5) → 1-oxo-2β-[3-butanone]-3α-methyl-6β-[2-propanol formyl ester]-cyclohexane (176022-28-9) + Acetic acid (3aS,4R,6aS,7R,10R,10aR)-4,7-dimethyl-octahydro-furo[3,2-i]isochromen-10-yl ester + 4α-hydroxy-1,10-deoxoartemisinin + C15H24O4

Guidance literature:

With iron(II) sulfate; In water; acetonitrile; at 23 ℃; for 24h; Further byproducts given;

DOI:10.1002/anie.200352343

Reference yield: 13.0%

(+)-deoxyartemisinin (126189-95-5) → (-)-deoxodesoxyartemisinin (104992-28-1) + 1-oxo-2β-[3-butanone]-3α-methyl-6β-[2-propanol formyl ester]-cyclohexane (176022-28-9) + Acetic acid (3aS,4R,6aS,7R,10R,10aR)-4,7-dimethyl-octahydro-furo[3,2-i]isochromen-10-yl ester + 4α-hydroxy-1,10-deoxoartemisinin

Guidance literature:

With iron(II) sulfate; In water; acetonitrile; at 23 ℃; for 24h; Further byproducts given;

DOI:10.1002/anie.200352343

Reference yield: 8.3%

10-deoxoartemisinin → 1,10-dideoxoartemisinin + 1-oxo-2β-[3-butanone]-3α-methyl-6β-[2-propanol formyl ester]-cyclohexane (176022-28-9)

Guidance literature:

With iron(II) bromide; In tetrahydrofuran; for 0.25h; Ambient temperature;

DOI:10.1021/jm950921y

upstream raw materials:

(+)-deoxyartemisinin