5-{[(3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]methyl}-3-(4-fluorophenyl)isoxazole

Base Information

Chemical Name:5-{[(3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]methyl}-3-(4-fluorophenyl)isoxazole
CAS No.:1620843-84-6
Molecular Formula:C₂₅H₂₈FNO₄
Molecular Weight:425.5
Hs Code.:

Synonyms:5-{[(3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]methyl}-3-(4-fluorophenyl)isoxazole

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Chemical Property of 5-{[(3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]methyl}-3-(4-fluorophenyl)isoxazole

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Technology Process of 5-{[(3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]methyl}-3-(4-fluorophenyl)isoxazole

There total 3 articles about 5-{[(3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]methyl}-3-(4-fluorophenyl)isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333118-59-4
3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2-(prop-2-ynyloxymethyl)-2Η-1-benzopyran

: 459-23-4,7304-35-0
4-fluorobenzaldoxime

: 1620843-84-6
5-{[(3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]methyl}-3-(4-fluorophenyl)isoxazole

Guidance literature:: With chloroamine-T; sodium hydroxide; In water; at 90 ℃; for 0.75h; pH=6; regiospecific reaction; Microwave irradiation; Green chemistry;
DOI:10.1016/j.ejmech.2014.06.046

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 1620843-84-6
5-{[(3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]methyl}-3-(4-fluorophenyl)isoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium hydroxide / tert-butyl alcohol; water / 20 °C

2: sodium hydroxide; chloroamine-T / water / 0.75 h / 90 °C / pH 6 / Microwave irradiation; Green chemistry

With hydroxylamine hydrochloride; chloroamine-T; sodium hydroxide; In water; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2014.06.046

Reference yield:

: 184879-62-7
3,4-dihydro-6-methoxy-2,5 ,7,8-tetramethyl-2H-benzopyran-2-methanol

: 1620843-84-6
5-{[(3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]methyl}-3-(4-fluorophenyl)isoxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C

1.2: 0 - 20 °C

2.1: sodium hydroxide; chloroamine-T / water / 0.75 h / 90 °C / pH 6 / Microwave irradiation; Green chemistry

With chloroamine-T; sodium hydride; sodium hydroxide; In tetrahydrofuran; water; mineral oil;
DOI:10.1016/j.ejmech.2014.06.046