(2R,3S)-3-Amino-3-(4-dimethylamino-phenyl)-2-hydroxy-propionic acid methyl ester

Base Information

Chemical Name:(2R,3S)-3-Amino-3-(4-dimethylamino-phenyl)-2-hydroxy-propionic acid methyl ester
CAS No.:157157-65-8
Molecular Formula:C₁₂H₁₈N₂O₃
Molecular Weight:238.287
Hs Code.:

Synonyms:(2R,3S)-3-Amino-3-(4-dimethylamino-phenyl)-2-hydroxy-propionic acid methyl ester

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Chemical Property of (2R,3S)-3-Amino-3-(4-dimethylamino-phenyl)-2-hydroxy-propionic acid methyl ester

Chemical Property:

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Technology Process of (2R,3S)-3-Amino-3-(4-dimethylamino-phenyl)-2-hydroxy-propionic acid methyl ester

There total 3 articles about (2R,3S)-3-Amino-3-(4-dimethylamino-phenyl)-2-hydroxy-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 154306-90-8
methyl (2R,3S)-2-hydroxy-3-[(S)-1-phenyl]ethylamino-3-(4-dimethylaminophenyl)propionate

: 157157-65-8
(2R,3S)-3-Amino-3-(4-dimethylamino-phenyl)-2-hydroxy-propionic acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; acetic acid; at 65 ℃; for 4h; under 17841.6 Torr;
DOI:10.1016/S0040-4039(00)61724-0

Reference yield:

: Acetic acid (2R,3S)-2-(4-dimethylamino-phenyl)-4-oxo-1-((S)-1-phenyl-ethyl)-azetidin-3-yl ester

: 157157-65-8
(2R,3S)-3-Amino-3-(4-dimethylamino-phenyl)-2-hydroxy-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / potassium hydroxide 1M H₂O / tetrahydrofuran / 1 h / 0 °C

2: 89 percent / hydrogen chloride gas / 2.5 h / 40 °C

3: hydrogen / palladium/C 3percent / methanol; acetic acid / 4 h / 65 °C / 17841.6 Torr

With hydrogenchloride; potassium hydroxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid;
DOI:10.1016/S0040-4039(00)61724-0

Reference yield:

: 154306-89-5
(3R,4S)-3-hydroxy-4-(4-dimethylaminophenyl)-1-[(S)-1-phenyl]ethyl-2-azetidinone

: 157157-65-8
(2R,3S)-3-Amino-3-(4-dimethylamino-phenyl)-2-hydroxy-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / hydrogen chloride gas / 2.5 h / 40 °C

2: hydrogen / palladium/C 3percent / methanol; acetic acid / 4 h / 65 °C / 17841.6 Torr

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; acetic acid;
DOI:10.1016/S0040-4039(00)61724-0