Technology Process of (3-benzyl-2'-ethyl-2''-isopropyl-[1,1',4',1'']terphenyl-4''-yloxy)acetic acid benzyl ester
There total 16 articles about (3-benzyl-2'-ethyl-2''-isopropyl-[1,1',4',1'']terphenyl-4''-yloxy)acetic acid benzyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 6.9 g / H2 / Pd/C / methanol / 5 h / 3102.97 Torr
2.1: DIEA / CH2Cl2 / 1 h
3.1: t-butyllithium / hexane; tetrahydrofuran / 0.25 h / -78 °C
3.2: zinc chloride / tetrahydrofuran; hexane / 0.5 h / 0 °C
3.3: tris(dibenzylideneacetone)dipalladium; 1,1'-bis(diphenylphosphino)-ferrocene / tetrahydrofuran; various solvent(s) / Heating
4.1: TBAF / tetrahydrofuran / 0.5 h / 0 °C
5.1: DIEA / CH2Cl2 / 1 h
6.1: t-butyllithium / hexane; tetrahydrofuran / 0.25 h / -78 °C
6.2: zinc chloride / tetrahydrofuran; various solvent(s) / 0.5 h / 0 °C
6.3: tris(dibenzylideneacetone)dipalladium; 1,1'-bis(diphenylphosphino)-ferrocene / tetrahydrofuran; hexane / Heating
7.1: TBAF / tetrahydrofuran / 0.5 h / 0 °C
8.1: K2CO3 / dimethylformamide / 1 h / Heating
With
tetrabutyl ammonium fluoride; hydrogen; tert.-butyl lithium; potassium carbonate; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja0025548
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: tetrahydrofuran / 1 h / Heating
2.1: 6.9 g / H2 / Pd/C / methanol / 5 h / 3102.97 Torr
3.1: DIEA / CH2Cl2 / 1 h
4.1: t-butyllithium / hexane; tetrahydrofuran / 0.25 h / -78 °C
4.2: zinc chloride / tetrahydrofuran; hexane / 0.5 h / 0 °C
4.3: tris(dibenzylideneacetone)dipalladium; 1,1'-bis(diphenylphosphino)-ferrocene / tetrahydrofuran; various solvent(s) / Heating
5.1: TBAF / tetrahydrofuran / 0.5 h / 0 °C
6.1: DIEA / CH2Cl2 / 1 h
7.1: t-butyllithium / hexane; tetrahydrofuran / 0.25 h / -78 °C
7.2: zinc chloride / tetrahydrofuran; various solvent(s) / 0.5 h / 0 °C
7.3: tris(dibenzylideneacetone)dipalladium; 1,1'-bis(diphenylphosphino)-ferrocene / tetrahydrofuran; hexane / Heating
8.1: TBAF / tetrahydrofuran / 0.5 h / 0 °C
9.1: K2CO3 / dimethylformamide / 1 h / Heating
With
tetrabutyl ammonium fluoride; hydrogen; tert.-butyl lithium; potassium carbonate; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja0025548
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: tetrahydrofuran / 1 h / Heating
2.1: 6.9 g / H2 / Pd/C / methanol / 5 h / 3102.97 Torr
3.1: DIEA / CH2Cl2 / 1 h
4.1: t-butyllithium / hexane; tetrahydrofuran / 0.25 h / -78 °C
4.2: zinc chloride / tetrahydrofuran; hexane / 0.5 h / 0 °C
4.3: tris(dibenzylideneacetone)dipalladium; 1,1'-bis(diphenylphosphino)-ferrocene / tetrahydrofuran; various solvent(s) / Heating
5.1: TBAF / tetrahydrofuran / 0.5 h / 0 °C
6.1: DIEA / CH2Cl2 / 1 h
7.1: t-butyllithium / hexane; tetrahydrofuran / 0.25 h / -78 °C
7.2: zinc chloride / tetrahydrofuran; various solvent(s) / 0.5 h / 0 °C
7.3: tris(dibenzylideneacetone)dipalladium; 1,1'-bis(diphenylphosphino)-ferrocene / tetrahydrofuran; hexane / Heating
8.1: TBAF / tetrahydrofuran / 0.5 h / 0 °C
9.1: K2CO3 / dimethylformamide / 1 h / Heating
With
tetrabutyl ammonium fluoride; hydrogen; tert.-butyl lithium; potassium carbonate; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja0025548
