tert-butyl 4-[3-({4-methyl-3-[6-(1H-pyrazol-4-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-carbamoyl)-5-(pentafluoro-λ⁶-sulphanyl)phenyl]piperazin-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-[3-({4-methyl-3-[6-(1H-pyrazol-4-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-carbamoyl)-5-(pentafluoro-λ⁶-sulphanyl)phenyl]piperazin-1-carboxylate
• CAS No.: 1448317-81-4
• Molecular Formula: C₃₁H₃₃F₅N₈O₃S
• Molecular Weight: 692.713

Synonyms:tert-butyl 4-[3-({4-methyl-3-[6-(1H-pyrazol-4-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-carbamoyl)-5-(pentafluoro-λ⁶-sulphanyl)phenyl]piperazin-1-carboxylate

Chemical Property of tert-butyl 4-[3-({4-methyl-3-[6-(1H-pyrazol-4-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-carbamoyl)-5-(pentafluoro-λ⁶-sulphanyl)phenyl]piperazin-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-[3-({4-methyl-3-[6-(1H-pyrazol-4-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-carbamoyl)-5-(pentafluoro-λ⁶-sulphanyl)phenyl]piperazin-1-carboxylate

There total 7 articles about tert-butyl 4-[3-({4-methyl-3-[6-(1H-pyrazol-4-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-carbamoyl)-5-(pentafluoro-λ⁶-sulphanyl)phenyl]piperazin-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-3-[6-(1H-pyrazol-4-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]aniline (1448317-26-7) + 3-[4-(tert-butoxycarbonyl)piperazin-1-yl]-5-(pentafluoro-λ6-sulphanyl)benzoic acid (1448317-49-4) → tert-butyl 4-[3-({4-methyl-3-[6-(1H-pyrazol-4-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-carbamoyl)-5-(pentafluoro-λ6-sulphanyl)phenyl]piperazin-1-carboxylate (1448317-81-4)

Guidance literature:

3-[4-(tert-butoxycarbonyl)piperazin-1-yl]-5-(pentafluoro-λ⁶-sulphanyl)benzoic acid; With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

4-methyl-3-[6-(1H-pyrazol-4-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]aniline; In N,N-dimethyl-formamide; at -5 - 20 ℃; for 16h;

Reference yield:

1-(2,2-diethoxyethyl)-N-(2-methyl-5-nitrophenyl)-1'-(tetrahydro-2H-pyran-2-yl)-1H,1'H-3,4'-bipyrazole-5-amine (1448317-24-5) → tert-butyl 4-[3-({4-methyl-3-[6-(1H-pyrazol-4-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-carbamoyl)-5-(pentafluoro-λ6-sulphanyl)phenyl]piperazin-1-carboxylate (1448317-81-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sulfuric acid / ethanol / 0.25 h / 120 °C / Microwave irradiation

2.1: palladium 10% on activated carbon / ethanol; cyclohexene / 16 h / Inert atmosphere; Reflux

3.1: HATU; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 16 h / -5 - 20 °C

With 4-methyl-morpholine; sulfuric acid; palladium 10% on activated carbon; HATU; In ethanol; N,N-dimethyl-formamide; cyclohexene;

Reference yield:

1-(2-methyl-5-nitrophenyl)-6-(1H-pyrazol-4-yl)-1H-imidazo[1,2-b]pyrazole (1448317-25-6) → tert-butyl 4-[3-({4-methyl-3-[6-(1H-pyrazol-4-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-carbamoyl)-5-(pentafluoro-λ6-sulphanyl)phenyl]piperazin-1-carboxylate (1448317-81-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon / ethanol; cyclohexene / 16 h / Inert atmosphere; Reflux

2.1: HATU; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 16 h / -5 - 20 °C

With 4-methyl-morpholine; palladium 10% on activated carbon; HATU; In ethanol; N,N-dimethyl-formamide; cyclohexene;

upstream raw materials:

4-methyl-3-[6-(1H-pyrazol-4-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]aniline

3-[4-(tert-butoxycarbonyl)piperazin-1-yl]-5-(pentafluoro-λ⁶-sulphanyl)benzoic acid

1-(2,2-diethoxyethyl)-N-(2-methyl-5-nitrophenyl)-1'-(tetrahydro-2H-pyran-2-yl)-1H,1'H-3,4'-bipyrazole-5-amine

1-(2-methyl-5-nitrophenyl)-6-(1H-pyrazol-4-yl)-1H-imidazo[1,2-b]pyrazole

Downstream raw materials:

N-{4-methyl-3-[6-(1H-pyrazol-4-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-3-(pentafluoro-λ⁶-sulphanyl)-5-(piperazin-1-yl)benzamide

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