docosyl (6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-yl-amino)acetate

Base Information

Chemical Name:docosyl (6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-yl-amino)acetate
CAS No.:1273387-13-5
Molecular Formula:C₄₅H₆₅N₅O₄S₂
Molecular Weight:804.174
Hs Code.:

Synonyms:docosyl (6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-yl-amino)acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of docosyl (6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-yl-amino)acetate

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Technology Process of docosyl (6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-yl-amino)acetate

There total 10 articles about docosyl (6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-yl-amino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 123253-22-5
docosyl mesylate

: 1187450-51-6
(6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)-acetic acid

: 1273387-13-5
docosyl (6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-yl-amino)acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 5h;

Reference yield:

: 203321-86-2
6-tert-butoxycarbonylamino-pyridine-2-carboxylic acid ethyl ester

: 1273387-13-5
docosyl (6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-yl-amino)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.33 h / 20 °C / Inert atmosphere; Cooling with ice

1.2: 1.17 h / 20 °C / Cooling with ice

2.1: ethanol; calcium chloride; sodium tetrahydroborate / Tetraethylene glycol dimethyl ether / 35 °C / Cooling with ice

2.2: 1.17 h / 29 °C / Cooling with ice

3.1: tributylphosphine; diamide / tetrahydrofuran / 12 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 50 h / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 50 °C

With hydrogenchloride; sodium tetrahydroborate; ethanol; tributylphosphine; diamide; sodium hydride; potassium carbonate; calcium chloride; In tetrahydrofuran; 1,4-dioxane; Tetraethylene glycol dimethyl ether; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 454678-91-2
(4-(thiazol-2-yl)phenyl)methanol

: 1273387-13-5
docosyl (6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-yl-amino)acetate

Guidance literature:: Multi-step reaction with 7 steps

1: triphenylphosphine; N-Bromosuccinimide / tetrahydrofuran / 1.5 h / 20 °C

2: potassium carbonate / dichloromethane / 3 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4: triethylamine / dichloromethane / 3 h / 20 °C

5: tributylphosphine; diamide / tetrahydrofuran / 12 h / 20 °C

6: hydrogenchloride / 1,4-dioxane / 50 h / 20 °C

7: potassium carbonate / N,N-dimethyl-formamide / 5 h / 50 °C

With hydrogenchloride; N-Bromosuccinimide; tributylphosphine; diamide; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;