Fmoc-(Se)-phenylselenocysteine-ODpm

Base Information

• Chemical Name: Fmoc-(Se)-phenylselenocysteine-ODpm
• CAS No.: 342904-06-7
• Molecular Formula: C₃₇H₃₁NO₄Se
• Molecular Weight: 632.617
• Mol file: 342904-06-7.mol

Synonyms:Fmoc-(Se)-phenylselenocysteine-ODpm

Chemical Property of Fmoc-(Se)-phenylselenocysteine-ODpm

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Fmoc-(Se)-phenylselenocysteine-ODpm

There total 4 articles about Fmoc-(Se)-phenylselenocysteine-ODpm which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

Benzeneselenol (645-96-5) + Fmoc-(OTs)-serine-ODpm (342904-05-6) → Fmoc-(Se)-phenylselenocysteine-ODpm (342904-06-7)

Guidance literature:

With sodium hydroxide; In water; N,N-dimethyl-formamide; acetone; at 0 ℃; for 3.5h;

DOI:10.1021/ol015712o

Reference yield:

N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine (73724-45-5) → Fmoc-(Se)-phenylselenocysteine-ODpm (342904-06-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 68 percent / PhI(OAc)2; I₂ / CH₂Cl₂ / -10 - 0 °C

2: 73 percent / pyridine / 0 °C

3: 75 percent / NaOH / dimethylformamide; H₂O; acetone / 3.5 h / 0 °C

With pyridine; sodium hydroxide; [bis(acetoxy)iodo]benzene; iodine; In dichloromethane; water; N,N-dimethyl-formamide; acetone;

DOI:10.1021/ol015712o

Reference yield:

benzophenone hydrazone (5350-57-2) → Fmoc-(Se)-phenylselenocysteine-ODpm (342904-06-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 68 percent / PhI(OAc)2; I₂ / CH₂Cl₂ / -10 - 0 °C

2: 73 percent / pyridine / 0 °C

3: 75 percent / NaOH / dimethylformamide; H₂O; acetone / 3.5 h / 0 °C

With pyridine; sodium hydroxide; [bis(acetoxy)iodo]benzene; iodine; In dichloromethane; water; N,N-dimethyl-formamide; acetone;

DOI:10.1021/ol015712o

upstream raw materials:

Benzeneselenol

Fmoc-(OTs)-serine-ODpm

benzophenone hydrazone

benzyhydryl N-[9-(fluorenylmethoxycarbonyl)]-L-serinate

Downstream raw materials:

N-(9-fluorenylmethoxycarbonyl)-L-β-phenylselenocysteine