1-bromo-4-[(1α,5α,6β)-3-tert-butoxycarbonyl-6-cyano-3-azabicyclo[3.1.0]hexan-6-yl]-3,5-difluorobenzene

Base Information

• Chemical Name: 1-bromo-4-[(1α,5α,6β)-3-tert-butoxycarbonyl-6-cyano-3-azabicyclo[3.1.0]hexan-6-yl]-3,5-difluorobenzene
• CAS No.: 831202-94-9
• Molecular Formula: C₁₇H₁₇BrF₂N₂O₂
• Molecular Weight: 399.235
• Mol file: 831202-94-9.mol

Synonyms:1-bromo-4-[(1α,5α,6β)-3-tert-butoxycarbonyl-6-cyano-3-azabicyclo[3.1.0]hexan-6-yl]-3,5-difluorobenzene

Chemical Property of 1-bromo-4-[(1α,5α,6β)-3-tert-butoxycarbonyl-6-cyano-3-azabicyclo[3.1.0]hexan-6-yl]-3,5-difluorobenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-bromo-4-[(1α,5α,6β)-3-tert-butoxycarbonyl-6-cyano-3-azabicyclo[3.1.0]hexan-6-yl]-3,5-difluorobenzene

There total 1 articles about 1-bromo-4-[(1α,5α,6β)-3-tert-butoxycarbonyl-6-cyano-3-azabicyclo[3.1.0]hexan-6-yl]-3,5-difluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

2-(4-bromo-2,6-difluorophenyl)acetonitrile (537033-52-6) + cis-N-tert-butoxycarbonylpyrrolidine-3,4-cyclic sulfate (831203-12-4) → 1-bromo-4-[(1α,5α,6β)-3-tert-butoxycarbonyl-6-cyano-3-azabicyclo[3.1.0]hexan-6-yl]-3,5-difluorobenzene (831202-94-9)

Guidance literature:

With sodium hydride; In 1,2-dimethoxyethane; mineral oil; at 0 - 20 ℃; stereoselective reaction;

DOI:10.1021/jm800800c

Reference yield: 93.0%

(5R)-3-[3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-one (700370-33-8) + 1-bromo-4-[(1α,5α,6β)-3-tert-butoxycarbonyl-6-cyano-3-azabicyclo[3.1.0]hexan-6-yl]-3,5-difluorobenzene (831202-94-9) → 1-[5(R)-3-[4-[4-[(1α,5α,6β)-3-tert-butoxycarbonyl-6-cyano-3-azabicyclo[3.1.0]hexan-6-yl]-3,5-difluorophenyl]-3-fluorophenyl]-2-oxooxazolidin-5-ylmethyl]-1,2,3-triazole

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 80 ℃; for 3h;

DOI:10.1021/jm800800c

upstream raw materials:

2-(4-bromo-2,6-difluorophenyl)acetonitrile

cis-N-tert-butoxycarbonylpyrrolidine-3,4-cyclic sulfate