tert-butyl 2-(5-(2-fluoro-6-hydroxy-4-(1H-pyrazol-4-yl)phenyl)-1,3,4-thiadiazol-2-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate

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Chemical Name:tert-butyl 2-(5-(2-fluoro-6-hydroxy-4-(1H-pyrazol-4-yl)phenyl)-1,3,4-thiadiazol-2-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate
CAS No.:1620516-17-7
Molecular Formula:C₂₃H₂₇FN₆O₃S
Molecular Weight:486.57
Hs Code.:

Synonyms:tert-butyl 2-(5-(2-fluoro-6-hydroxy-4-(1H-pyrazol-4-yl)phenyl)-1,3,4-thiadiazol-2-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate

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Chemical Property of tert-butyl 2-(5-(2-fluoro-6-hydroxy-4-(1H-pyrazol-4-yl)phenyl)-1,3,4-thiadiazol-2-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate

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Technology Process of tert-butyl 2-(5-(2-fluoro-6-hydroxy-4-(1H-pyrazol-4-yl)phenyl)-1,3,4-thiadiazol-2-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate

There total 6 articles about tert-butyl 2-(5-(2-fluoro-6-hydroxy-4-(1H-pyrazol-4-yl)phenyl)-1,3,4-thiadiazol-2-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1620516-16-6
tert-butyl 2-(5-(2-(benzyloxy)-6-fluoro-4-(1H-pyrazol-4-yl)phenyl)-1,3,4-thiadiazol-2-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate

: 1620516-17-7
tert-butyl 2-(5-(2-fluoro-6-hydroxy-4-(1H-pyrazol-4-yl)phenyl)-1,3,4-thiadiazol-2-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane; at 20 ℃; for 156h; Inert atmosphere;

Reference yield:

: 183065-68-1
4-bromo-2,6-difluorobenzoic acid

: 1620516-17-7
tert-butyl 2-(5-(2-fluoro-6-hydroxy-4-(1H-pyrazol-4-yl)phenyl)-1,3,4-thiadiazol-2-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: trichlorophosphate / 3 h / 78 °C / Inert atmosphere; Cooling with ice

2: sodium hydride / tetrahydrofuran; mineral oil / 19 h / 20 - 50 °C / Cooling with ice

3: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 18 h / 20 °C

4: triethylamine / 1,4-dioxane / 3 h / 120 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

6: palladium 10% on activated carbon; hydrogen / methanol; dichloromethane / 156 h / 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; palladium 10% on activated carbon; hydrogen; sodium hydride; sodium carbonate; triethylamine; copper(ll) bromide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetonitrile; mineral oil;

Reference yield:

: 1620516-14-4
2-(2-(benzyloxy)-4-bromo-6-fluorophenyl)-5-bromo-1,3,4-thiadiazole

: 1620516-17-7
tert-butyl 2-(5-(2-fluoro-6-hydroxy-4-(1H-pyrazol-4-yl)phenyl)-1,3,4-thiadiazol-2-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / 1,4-dioxane / 3 h / 120 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

3: palladium 10% on activated carbon; hydrogen / methanol; dichloromethane / 156 h / 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium carbonate; triethylamine; In 1,4-dioxane; methanol; dichloromethane; water;