(4-{5-[4-(5-{4-[(S)-2-(Bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-pentyl)-piperazin-1-yl]-pentyloxy}-5-methoxy-2-nitro-phenyl)-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-methanone

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Chemical Name:(4-{5-[4-(5-{4-[(S)-2-(Bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-pentyl)-piperazin-1-yl]-pentyloxy}-5-methoxy-2-nitro-phenyl)-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-methanone
CAS No.:871813-92-2
Molecular Formula:C₄₈H₇₄N₆O₁₀S₄
Molecular Weight:1023.41
Hs Code.:

(4-{5-[4-(5-{4-[(S)-2-(Bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-pentyl)-piperazin-1-yl]-pentyloxy}-5-methoxy-2-nitro-phenyl)-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-methanone

Synonyms:(4-{5-[4-(5-{4-[(S)-2-(Bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-pentyl)-piperazin-1-yl]-pentyloxy}-5-methoxy-2-nitro-phenyl)-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-methanone

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Chemical Property of (4-{5-[4-(5-{4-[(S)-2-(Bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-pentyl)-piperazin-1-yl]-pentyloxy}-5-methoxy-2-nitro-phenyl)-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-methanone

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Technology Process of (4-{5-[4-(5-{4-[(S)-2-(Bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-pentyl)-piperazin-1-yl]-pentyloxy}-5-methoxy-2-nitro-phenyl)-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-methanone

There total 7 articles about (4-{5-[4-(5-{4-[(S)-2-(Bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-pentyl)-piperazin-1-yl]-pentyloxy}-5-methoxy-2-nitro-phenyl)-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 110-85-0
piperazine

: 343308-57-6
(2S)-N-[4-(5-bromopentyloxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal

: 871813-92-2
(4-{5-[4-(5-{4-[(S)-2-(Bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-pentyl)-piperazin-1-yl]-pentyloxy}-5-methoxy-2-nitro-phenyl)-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-methanone

Guidance literature:: With potassium carbonate; In acetone; for 48h; Heating;
DOI:10.1016/j.bmc.2005.08.020

Reference yield:

: 111-24-0
1,5-dibromo-pentane

: 871813-92-2
(4-{5-[4-(5-{4-[(S)-2-(Bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-pentyl)-piperazin-1-yl]-pentyloxy}-5-methoxy-2-nitro-phenyl)-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 6 steps

1: 83 percent / potassium carbonate / acetone / 48 h / Heating

2: 91 percent / stannic chloride; fuming nitric acid / CH₂Cl₂ / 0.08 h / -25 °C

3: 91 percent / lithium hydroxide monohydrate / tetrahydrofuran; H₂O; methanol / 12 h / 20 °C

4: thionyl chloride; DMF / benzene / 6 h

5: 505 mg / triethylamine / tetrahydrofuran; H₂O

6: 90 percent / potassium carbonate / acetone / 48 h / Heating

With lithium hydroxide; thionyl chloride; nitric acid; tin(IV) chloride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; water; acetone; benzene;
DOI:10.1016/j.bmc.2005.08.020

Reference yield:

: 3943-74-6
4-hydroxy-3-methoxybenzoic acid methyl ester

: 871813-92-2
(4-{5-[4-(5-{4-[(S)-2-(Bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-pentyl)-piperazin-1-yl]-pentyloxy}-5-methoxy-2-nitro-phenyl)-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 6 steps

1: 83 percent / potassium carbonate / acetone / 48 h / Heating

2: 91 percent / stannic chloride; fuming nitric acid / CH₂Cl₂ / 0.08 h / -25 °C

3: 91 percent / lithium hydroxide monohydrate / tetrahydrofuran; H₂O; methanol / 12 h / 20 °C

4: thionyl chloride; DMF / benzene / 6 h

5: 505 mg / triethylamine / tetrahydrofuran; H₂O

6: 90 percent / potassium carbonate / acetone / 48 h / Heating

With lithium hydroxide; thionyl chloride; nitric acid; tin(IV) chloride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; water; acetone; benzene;
DOI:10.1016/j.bmc.2005.08.020