N-{1-[2-(1-Ethyl-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-ethyl]-4-methoxymethyl-piperidin-4-yl}-N-phenyl-propionamide

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Chemical Name:N-{1-[2-(1-Ethyl-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-ethyl]-4-methoxymethyl-piperidin-4-yl}-N-phenyl-propionamide
CAS No.:131729-05-0
Molecular Formula:C₂₈H₃₆N₄O₄
Molecular Weight:492.618
Hs Code.:

Synonyms:N-{1-[2-(1-Ethyl-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-ethyl]-4-methoxymethyl-piperidin-4-yl}-N-phenyl-propionamide

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Chemical Property of N-{1-[2-(1-Ethyl-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-ethyl]-4-methoxymethyl-piperidin-4-yl}-N-phenyl-propionamide

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Technology Process of N-{1-[2-(1-Ethyl-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-ethyl]-4-methoxymethyl-piperidin-4-yl}-N-phenyl-propionamide

There total 2 articles about N-{1-[2-(1-Ethyl-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-ethyl]-4-methoxymethyl-piperidin-4-yl}-N-phenyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 61086-18-8
N-[4-(methoxymethyl)-4-piperidinyl]-N-phenylpropanamide

: 131729-07-2
3-(2-Bromo-ethyl)-1-ethyl-1H-quinazoline-2,4-dione

: 131729-05-0
N-{1-[2-(1-Ethyl-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-ethyl]-4-methoxymethyl-piperidin-4-yl}-N-phenyl-propionamide

Guidance literature:: With sodium carbonate; sodium iodide; In acetonitrile; Heating;
DOI:10.1021/jm00106a051

Reference yield:

: 2217-25-6
1-ethyl-1,2,3,4-tetrahydro-2,4-quinazolinedione

: 131729-05-0
N-{1-[2-(1-Ethyl-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-ethyl]-4-methoxymethyl-piperidin-4-yl}-N-phenyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 2.) a) DMF, RT, 30 min, b) reflux, 3 d

2: 72 percent / Na₂CO₃, NaI / acetonitrile / Heating

With sodium hydride; sodium carbonate; sodium iodide; In acetonitrile;
DOI:10.1021/jm00106a051