4-methoxy-6,7-methylenedioxy-4-trifluoromethyl-1-[4-(trifluoromethyl)styryl]-3,4-dihydroisoquinoline

Base Information

Chemical Name:4-methoxy-6,7-methylenedioxy-4-trifluoromethyl-1-[4-(trifluoromethyl)styryl]-3,4-dihydroisoquinoline
CAS No.:324076-80-4
Molecular Formula:C₂₁H₁₅F₆NO₃
Molecular Weight:443.345
Hs Code.:

Synonyms:4-methoxy-6,7-methylenedioxy-4-trifluoromethyl-1-[4-(trifluoromethyl)styryl]-3,4-dihydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-methoxy-6,7-methylenedioxy-4-trifluoromethyl-1-[4-(trifluoromethyl)styryl]-3,4-dihydroisoquinoline

Chemical Property:

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Technology Process of 4-methoxy-6,7-methylenedioxy-4-trifluoromethyl-1-[4-(trifluoromethyl)styryl]-3,4-dihydroisoquinoline

There total 5 articles about 4-methoxy-6,7-methylenedioxy-4-trifluoromethyl-1-[4-(trifluoromethyl)styryl]-3,4-dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 324076-79-1
N-[2-methoxy-2-(3,4-methylenedioxyphenyl)-2-(trifluoromethyl)ethyl]-4-(trifluoromethyl)cinnamic amide

: 324076-80-4
4-methoxy-6,7-methylenedioxy-4-trifluoromethyl-1-[4-(trifluoromethyl)styryl]-3,4-dihydroisoquinoline

Guidance literature:: With trichlorophosphate; at 90 ℃; for 16h;
DOI:10.1016/S0040-4020(01)00836-5

Reference yield:

: 105919-36-6,120681-07-4
trans-4-(trifluoromethyl)cinnamoyl chloride

: 324076-80-4
4-methoxy-6,7-methylenedioxy-4-trifluoromethyl-1-[4-(trifluoromethyl)styryl]-3,4-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / Na₂CO₃ / diethyl ether; H₂O / 2 h / 0 - 20 °C

2: 55 percent / POCl₃ / 16 h / 90 °C

With sodium carbonate; trichlorophosphate; In diethyl ether; water; 2: Pictet-Gams cyclisation;
DOI:10.1016/S0040-4020(01)00836-5

Reference yield:

: 102124-73-2
α,α,α-trifluoro-3,4-methylenedioxyacetophenone

: 324076-80-4
4-methoxy-6,7-methylenedioxy-4-trifluoromethyl-1-[4-(trifluoromethyl)styryl]-3,4-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaCN / 1,2-dimethoxy-ethane / 0.25 h / 20 °C

1.2: 71 percent / K₂CO₂ / 1,2-dimethoxy-ethane / 3 h / 20 °C

2.1: 68 percent / NaBH₄; CoCl₂ / methanol / 0 - 20 °C

3.1: 85 percent / Na₂CO₃ / diethyl ether; H₂O / 2 h / 0 - 20 °C

4.1: 55 percent / POCl₃ / 16 h / 90 °C

With sodium tetrahydroborate; sodium cyanide; sodium carbonate; trichlorophosphate; In methanol; 1,2-dimethoxyethane; diethyl ether; water; 4.1: Pictet-Gams cyclisation;
DOI:10.1016/S0040-4020(01)00836-5