C₂₁H₁₈N₄O₅

Base Information

Chemical Name:C₂₁H₁₈N₄O₅
CAS No.:1309611-46-8
Molecular Formula:C₂₁H₁₈N₄O₅
Molecular Weight:406.398
Hs Code.:

C<sub>21</sub>H<sub>18</sub>N<sub>4</sub>O<sub>5</sub>

Synonyms:C₂₁H₁₈N₄O₅

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Chemical Property of C₂₁H₁₈N₄O₅

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Technology Process of C₂₁H₁₈N₄O₅

There total 9 articles about C₂₁H₁₈N₄O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 36052-26-3
methyl 6-aminopyridine-2-carboxylate

: 1309611-45-7
C₁₄H₁₂N₂O₄

: 1309611-46-8
C₂₁H₁₈N₄O₅

Guidance literature:: C₁₄H₁₂N₂O₄; With 4-methyl-morpholine; chloroformic acid ethyl ester; In tetrahydrofuran; N,N-dimethyl-formamide; at -10 - -5 ℃; for 0.5h;

methyl 6-aminopyridine-2-carboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; at -10 - 90 ℃;
DOI:10.1021/ol2011083

Reference yield:

: 5453-67-8
2,6-bis(methoxycarbonyl)pyridine

: 1309611-46-8
C₂₁H₁₈N₄O₅

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide / water / 12 h / 20 °C

2: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran; N,N-dimethyl-formamide / 0.25 h / -10 - -5 °C

3: sodium azide / tetrahydrofuran; water; N,N-dimethyl-formamide / 0.5 h / Cooling

4: toluene / 30 h / 120 °C

5: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 3 h / 50 °C

6: tetrahydrofuran; N,N-dimethyl-formamide / 0 - 90 °C

With 4-methyl-morpholine; sodium azide; palladium 10% on activated carbon; hydrogen; chloroformic acid ethyl ester; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;
DOI:10.1039/c1cc11532d

Reference yield:

: 499-83-2
Pyridine-2,6-dicarboxylic acid

: 1309611-46-8
C₂₁H₁₈N₄O₅

Guidance literature:: Multi-step reaction with 7 steps

1: sulfuric acid / 48 h / Reflux

2: sodium hydroxide / water / 12 h / 20 °C

3: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran; N,N-dimethyl-formamide / 0.25 h / -10 - -5 °C

4: sodium azide / tetrahydrofuran; water; N,N-dimethyl-formamide / 0.5 h / Cooling

5: toluene / 30 h / 120 °C

6: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 3 h / 50 °C

7: tetrahydrofuran; N,N-dimethyl-formamide / 0 - 90 °C

With 4-methyl-morpholine; sodium azide; sulfuric acid; palladium 10% on activated carbon; hydrogen; chloroformic acid ethyl ester; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;
DOI:10.1039/c1cc11532d