N-[6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-8-(9H-fluoren-2-ylamino)-9H-purin-2-yl]-2-(4-isopropyl-phenoxy)-acetamide

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Chemical Name:N-[6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-8-(9H-fluoren-2-ylamino)-9H-purin-2-yl]-2-(4-isopropyl-phenoxy)-acetamide
CAS No.:479408-40-7
Molecular Formula:C₅₃H₆₈N₆O₆Si₂
Molecular Weight:941.331
Hs Code.:

<i>N</i>-[6-benzyloxy-9-[4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-5-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-8-(9<i>H</i>-fluoren-2-ylamino)-9<i>H</i>-purin-2-yl]-2-(4-isopropyl-phenoxy)-acetamide

Synonyms:N-[6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-8-(9H-fluoren-2-ylamino)-9H-purin-2-yl]-2-(4-isopropyl-phenoxy)-acetamide

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Chemical Property of N-[6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-8-(9H-fluoren-2-ylamino)-9H-purin-2-yl]-2-(4-isopropyl-phenoxy)-acetamide

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Technology Process of N-[6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-8-(9H-fluoren-2-ylamino)-9H-purin-2-yl]-2-(4-isopropyl-phenoxy)-acetamide

There total 1 articles about N-[6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-8-(9H-fluoren-2-ylamino)-9H-purin-2-yl]-2-(4-isopropyl-phenoxy)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 153-78-6
2-aminofluorene

: N-{6-benzyloxy-8-bromo-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-2-yl}-2-(4-isopropyl-phenoxy)-acetamide

: 479408-40-7
N-[6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-8-(9H-fluoren-2-ylamino)-9H-purin-2-yl]-2-(4-isopropyl-phenoxy)-acetamide

Guidance literature:: With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; potassium carbonate; In 1,4-dioxane; at 80 ℃; for 120h;
DOI:10.1021/ol026474f

Reference yield:

: 479408-40-7
N-[6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-8-(9H-fluoren-2-ylamino)-9H-purin-2-yl]-2-(4-isopropyl-phenoxy)-acetamide

: 479408-38-3
8-(N-acetyl-2-amino-fluorene)-N²-(p-isopropylphenoxyacetyl)-2'-deoxyguanosine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; 4-(dimethylamino)pyridine; pyridine

2: 79 percent / tetra-n-butylammonium fluoride; acetic acid / tetrahydrofuran / 20 °C

3: 88 percent / cyclohexene / Pd/C / ethanol / 3 h / Heating

With pyridine; dmap; tetrabutyl ammonium fluoride; acetic acid; triethylamine; cyclohexene; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/ol026474f

Reference yield:

: 479408-40-7
N-[6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-8-(9H-fluoren-2-ylamino)-9H-purin-2-yl]-2-(4-isopropyl-phenoxy)-acetamide

: 479408-42-9
8-(N-acetyl-2-amino-fluorene)-O⁶-benzyl-N²-(p-isopropylphenoxyacetyl)-2'-deoxyguanosine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; 4-(dimethylamino)pyridine; pyridine

2: 79 percent / tetra-n-butylammonium fluoride; acetic acid / tetrahydrofuran / 20 °C

With pyridine; dmap; tetrabutyl ammonium fluoride; acetic acid; triethylamine; In tetrahydrofuran;
DOI:10.1021/ol026474f