1-<(1β,2α)-<3-(tert-butyldiphenylsilyloxymethyl)-2-fluoro>cyclopent-3-enyl>-5-methylpyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:1-<(1β,2α)-<3-(tert-butyldiphenylsilyloxymethyl)-2-fluoro>cyclopent-3-enyl>-5-methylpyrimidine-2,4(1H,3H)-dione
CAS No.:135387-42-7
Molecular Formula:C₂₇H₃₁FN₂O₃Si
Molecular Weight:478.639
Hs Code.:

Synonyms:1-<(1β,2α)-<3-(tert-butyldiphenylsilyloxymethyl)-2-fluoro>cyclopent-3-enyl>-5-methylpyrimidine-2,4(1H,3H)-dione

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Chemical Property of 1-<(1β,2α)-<3-(tert-butyldiphenylsilyloxymethyl)-2-fluoro>cyclopent-3-enyl>-5-methylpyrimidine-2,4(1H,3H)-dione

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Technology Process of 1-<(1β,2α)-<3-(tert-butyldiphenylsilyloxymethyl)-2-fluoro>cyclopent-3-enyl>-5-methylpyrimidine-2,4(1H,3H)-dione

There total 5 articles about 1-<(1β,2α)-<3-(tert-butyldiphenylsilyloxymethyl)-2-fluoro>cyclopent-3-enyl>-5-methylpyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 135387-39-2,135500-90-2
1-[(1S,2S,3R,4R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-fluoro-4-hydroxy-cyclopentyl]-5-methyl-1H-pyrimidine-2,4-dione

: 135387-42-7
1-<(1β,2α)-<3-(tert-butyldiphenylsilyloxymethyl)-2-fluoro>cyclopent-3-enyl>-5-methylpyrimidine-2,4(1H,3H)-dione

: 135387-41-6
1-[(1S,2S,3R,4S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2,4-difluoro-cyclopentyl]-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at -30 - -25 ℃; for 0.5h;

Reference yield:

: 132151-65-6
(E)-3-methoxy-2-methylacryloyl isocyanate

: 135387-42-7
1-<(1β,2α)-<3-(tert-butyldiphenylsilyloxymethyl)-2-fluoro>cyclopent-3-enyl>-5-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / dimethylformamide; benzene / 1) -20 deg C to room temperature, 1 h, 2) room temperature, 15 h

2: 1) 4 M aq. HCl, 2) imidazole / 1) 1,4-dioxane, reflux, 1.5 h, 2) DMF, room temperature, 1 h

3: 75 percent / H₂ / 20percent Pd(OH)2/C / ethyl acetate; ethanol / 24 h / 760 Torr / Ambient temperature

4: 23 percent / diethylaminosulphur trifluoride (DAST) / CH₂Cl₂ / 0.5 h / -30 - -25 °C

With 1H-imidazole; hydrogenchloride; diethylamino-sulfur trifluoride; hydrogen; palladium dihydroxide; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; benzene;

Reference yield:

: 135387-37-0,135500-87-7
(1R,2R,3S,4S)-4-Benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-2-fluoro-cyclopentylamine

: 135387-42-7
1-<(1β,2α)-<3-(tert-butyldiphenylsilyloxymethyl)-2-fluoro>cyclopent-3-enyl>-5-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / dimethylformamide; benzene / 1) -20 deg C to room temperature, 1 h, 2) room temperature, 15 h

2: 1) 4 M aq. HCl, 2) imidazole / 1) 1,4-dioxane, reflux, 1.5 h, 2) DMF, room temperature, 1 h

3: 75 percent / H₂ / 20percent Pd(OH)2/C / ethyl acetate; ethanol / 24 h / 760 Torr / Ambient temperature

4: 23 percent / diethylaminosulphur trifluoride (DAST) / CH₂Cl₂ / 0.5 h / -30 - -25 °C

With 1H-imidazole; hydrogenchloride; diethylamino-sulfur trifluoride; hydrogen; palladium dihydroxide; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; benzene;