(S)-N-[(tert-butoxy)carbonyl]-γ-(3-benzoyluracil-1-yl)-β-homoalanine benzyl ester

Base Information

Chemical Name:(S)-N-[(tert-butoxy)carbonyl]-γ-(3-benzoyluracil-1-yl)-β-homoalanine benzyl ester
CAS No.:517877-29-1
Molecular Formula:C₂₇H₂₉N₃O₇
Molecular Weight:507.543
Hs Code.:

Synonyms:(S)-N-[(tert-butoxy)carbonyl]-γ-(3-benzoyluracil-1-yl)-β-homoalanine benzyl ester

Suppliers and Price of (S)-N-[(tert-butoxy)carbonyl]-γ-(3-benzoyluracil-1-yl)-β-homoalanine benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-N-[(tert-butoxy)carbonyl]-γ-(3-benzoyluracil-1-yl)-β-homoalanine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-N-[(tert-butoxy)carbonyl]-γ-(3-benzoyluracil-1-yl)-β-homoalanine benzyl ester

There total 2 articles about (S)-N-[(tert-butoxy)carbonyl]-γ-(3-benzoyluracil-1-yl)-β-homoalanine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 79069-16-2
benzyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-hydroxybutanoate

: 2775-87-3
3-N-benzoyluracil

: 517877-29-1
(S)-N-[(tert-butoxy)carbonyl]-γ-(3-benzoyluracil-1-yl)-β-homoalanine benzyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at -15 ℃; for 96h;
DOI:10.1002/1522-2675(200211)85:11<3855::AID-HLCA3855>3.0.CO;2-A

Reference yield:

: 7536-58-5,98482-77-0
BOC-L-aspartic acid 4-benzyl ester

: 517877-29-1
(S)-N-[(tert-butoxy)carbonyl]-γ-(3-benzoyluracil-1-yl)-β-homoalanine benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: tBuOCOCl; NEM / tetrahydrofuran

1.2: 95 percent / NaBH₄ / methanol

2.1: 70 percent / DEAD; Ph₃P / tetrahydrofuran / 96 h / -15 °C

With N-Ethylmaleimide; tert-butyl chloroformate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 2.1: Mitsunobu reaction;
DOI:10.1002/1522-2675(200211)85:11<3855::AID-HLCA3855>3.0.CO;2-A

Reference yield:

: 517877-29-1
(S)-N-[(tert-butoxy)carbonyl]-γ-(3-benzoyluracil-1-yl)-β-homoalanine benzyl ester

: 517877-36-0
(S)-N-[(tert-butoxy)carbonyl]-γ-(uracil-1-yl)-β-homoalanine benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / H₂ / Pd/C / H₂O; dioxane; acetic acid

2: 86 percent / N-[3-(dimethylamino)propyl]-N'-ethylcarbodiimide HCl; DMAP / dimethylformamide / 16 h / 20 °C

With dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In 1,4-dioxane; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1002/1522-2675(200211)85:11<3855::AID-HLCA3855>3.0.CO;2-A