2-[3-(4-phenylpiperidin-1-yl)propyl]-3,4-dihydropyrazino[1,2-b]indazol-1(2H)-one

Base Information

Chemical Name:2-[3-(4-phenylpiperidin-1-yl)propyl]-3,4-dihydropyrazino[1,2-b]indazol-1(2H)-one
CAS No.:1338320-19-6
Molecular Formula:C₂₄H₂₈N₄O
Molecular Weight:388.513
Hs Code.:

Synonyms:2-[3-(4-phenylpiperidin-1-yl)propyl]-3,4-dihydropyrazino[1,2-b]indazol-1(2H)-one

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Chemical Property of 2-[3-(4-phenylpiperidin-1-yl)propyl]-3,4-dihydropyrazino[1,2-b]indazol-1(2H)-one

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Technology Process of 2-[3-(4-phenylpiperidin-1-yl)propyl]-3,4-dihydropyrazino[1,2-b]indazol-1(2H)-one

There total 7 articles about 2-[3-(4-phenylpiperidin-1-yl)propyl]-3,4-dihydropyrazino[1,2-b]indazol-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 15037-34-0
1-(3-Chloropropyl)-4-phenyl-1,2,4,6-tetrahydropyridine

: 1133065-96-9
3,4-dihydropyrazino[1,2-b]indazol-1(2H)-one

: 1338320-19-6
2-[3-(4-phenylpiperidin-1-yl)propyl]-3,4-dihydropyrazino[1,2-b]indazol-1(2H)-one

Guidance literature:: 3,4-dihydropyrazino[1,2-b]indazol-1(2H)-one; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 1h; Inert atmosphere;

1-(3-Chloropropyl)-4-phenyl-1,2,4,6-tetrahydropyridine; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; Reflux; Inert atmosphere;
DOI:10.1002/cmdc.201800199

Reference yield:

: 43120-28-1
methyl 1H-indazole-3-carboxylate

: 1338320-19-6
2-[3-(4-phenylpiperidin-1-yl)propyl]-3,4-dihydropyrazino[1,2-b]indazol-1(2H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / acetonitrile / 72 h / 20 °C

2.1: sodium azide / dimethyl sulfoxide / 20 °C

3.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol / 24 h / 20 °C / Parr system

3.2: 48 h / Reflux

4.1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere

4.2: 6 h / Reflux

With hydrogenchloride; sodium azide; hydrogen; sodium hydride; caesium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1338227-09-0
methyl 2-(2-azidoethyl)-2H-indazole-3-carboxylate

: 1338320-19-6
2-[3-(4-phenylpiperidin-1-yl)propyl]-3,4-dihydropyrazino[1,2-b]indazol-1(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol / 24 h / 20 °C / Parr system

1.2: 48 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere

2.2: 6 h / Reflux

With hydrogenchloride; hydrogen; sodium hydride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; mineral oil;